Pseudomonas aeruginosa PAO1, PA0393 (proC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004735 pyrroline-5-carboxylate reductase activity
TAS
Traceable Author Statement
ECO:0000304
traceable author statement used in manual assertion
8479442 Reviewed by curator
Biological Process GO:0006561 proline biosynthetic process
TAS
Traceable Author Statement
ECO:0000304
traceable author statement used in manual assertion
8479442 Reviewed by curator
Molecular Function GO:0004735 pyrroline-5-carboxylate reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00521
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00521
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006561 proline biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00521
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc L-ornithine degradation II (Stickland reaction) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCyc PROSYN-PWY L-proline biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
PseudoCyc ARG-PRO-PWY L-arginine degradation VI (arginase 2 pathway) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
PseudoCAP Arginine and proline metabolism ECO:0000037
not_recorded
PseudoCAP Urea cycle and metabolism of amino groups ECO:0000037
not_recorded
KEGG pae00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-proline biosynthesis II (from arginine) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00330 Arginine and proline metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc L-proline biosynthesis III InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
TIGRFAM TIGR00112 proC: pyrroline-5-carboxylate reductase IPR000304 Pyrroline-5-carboxylate reductase 6 267 8.4E-80
Gene3D G3DSA:3.40.50.720 2 164 5.4E-52
ProSitePatterns PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. IPR000304 Pyrroline-5-carboxylate reductase 223 245 -
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 5 160 1.6E-39
Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain 163 267 6.8E-38
Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. IPR000304 Pyrroline-5-carboxylate reductase 4 267 27.618
SUPERFAMILY SSF48179 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 162 270 1.87E-35
Gene3D G3DSA:1.10.3730.10 165 271 1.7E-42
PIRSF PIRSF000193 IPR000304 Pyrroline-5-carboxylate reductase 3 270 1.4E-82
Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal 5 99 2.2E-23

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.