Pseudomonas aeruginosa PAO1, PA0426 (mexB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0042910 xenobiotic transmembrane transporter activity
IGC
Inferred from Genomic Context 		ECO:0000317
genomic context evidence used in manual assertion		 8540696 Reviewed by curator
Biological Process GO:0006811 ion transport
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042908 xenobiotic transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0015562 efflux transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Membrane proteins Other PAO1 genes in this class
Antibiotic resistance and susceptibility Other PAO1 genes in this class
Transport of small molecules Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01501 beta-Lactam resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.70.1430:FF:000002 Efflux pump membrane transporter - - 572 673 3.5E-39
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 336 359 4.3E-113
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 726 814 0.0
FunFam G3DSA:1.20.1640.10:FF:000002 Efflux pump membrane transporter - - 857 1024 5.5E-81
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 572 673 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 470 493 4.3E-113
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 518 1025 0.0
Gene3D G3DSA:3.30.70.1320 Multidrug efflux transporter AcrB pore domain like - - 133 331 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 8 32 4.3E-113
FunFam G3DSA:3.30.2090.10:FF:000002 Efflux pump membrane transporter - - 726 814 1.1E-44
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 7 517 0.0
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 724 811 9.16E-23
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 38 130 1.8E-28
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 391 415 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 36 54 4.3E-113
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 135 330 2.04E-26
PANTHER PTHR32063 - IPR001036 Acriflavin resistance protein 2 1037 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 554 571 4.3E-113
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 1 1027 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 623 637 4.3E-113
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 180 278 0.0
FunFam G3DSA:1.20.1640.10:FF:000001 Efflux pump membrane transporter - - 321 511 7.4E-79
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 296 497 1.07E-49
NCBIfam TIGR00915 JCVI: efflux RND transporter permease subunit IPR004764 Multidrug resistance protein MdtF-like 1 1044 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 363 384 4.3E-113
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 38 822 0.0
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 182 271 1.07E-22
Gene3D G3DSA:3.30.70.1440 Multidrug efflux transporter AcrB pore domain - - 674 872 0.0
FunFam G3DSA:3.30.70.1430:FF:000001 Efflux pump membrane transporter - - 38 138 1.7E-36
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 445 468 4.3E-113
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 567 671 1.31E-30
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 808 1027 1.96E-46
FunFam G3DSA:3.30.2090.10:FF:000001 Efflux pump membrane transporter - - 180 278 1.5E-44

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.