Pseudomonas aeruginosa PAO1, PA0426 (mexB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006811 ion transport
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
Molecular Function GO:0015238 drug transmembrane transporter activity
IGC
Inferred from Genomic Context
ECO:0000317
genomic context evidence used in manual assertion
8540696 Reviewed by curator
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0015562 efflux transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006855 drug transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016021 integral component of membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Membrane proteins Other PAO1 genes in this class
Antibiotic resistance and susceptibility Other PAO1 genes in this class
Transport of small molecules Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01501 beta-Lactam resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF82866 808 1027 1.96E-46
TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 1 1044 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 336 359 4.3E-113
SUPERFAMILY SSF82714 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 182 271 1.07E-22
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 445 468 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 8 32 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 36 54 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 363 384 4.3E-113
Gene3D G3DSA:3.30.70.1440 671 722 0.0
Gene3D G3DSA:1.20.1640.10 333 514 0.0
Gene3D G3DSA:1.20.1640.10 515 568 0.0
Gene3D G3DSA:1.20.1640.10 868 1024 0.0
Gene3D G3DSA:3.30.70.1430 569 670 0.0
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 1 1027 0.0
SUPERFAMILY SSF82693 567 671 1.31E-30
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 623 637 4.3E-113
SUPERFAMILY SSF82714 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 724 811 9.16E-23
Gene3D G3DSA:3.30.70.1440 820 867 0.0
Gene3D G3DSA:3.30.2090.10 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 723 811 0.0
SUPERFAMILY SSF82693 274 330 2.04E-26
Gene3D G3DSA:3.30.70.1320 133 178 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 470 493 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 391 415 4.3E-113
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 554 571 4.3E-113
Gene3D G3DSA:3.30.70.1430 812 819 0.0
Gene3D G3DSA:1.20.1640.10 8 37 0.0
Gene3D G3DSA:3.30.70.1320 276 332 0.0
Gene3D G3DSA:3.30.70.1430 38 132 0.0
SUPERFAMILY SSF82866 296 497 1.07E-49
SUPERFAMILY SSF82693 135 182 2.04E-26
SUPERFAMILY SSF82693 38 130 1.8E-28
Gene3D G3DSA:3.30.2090.10 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 179 275 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.