Pseudomonas aeruginosa PAO1, PA0501 (bioF)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA0501
Name	bioF
Replicon	chromosome
Genomic location	560808 - 562013 (+ strand)
Transposon Mutants	1 transposon mutants in PAO1
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	NP_249192.1
GI	15595698
Affymetrix	PA0501_bioF_at
Entrez	879619
GenBank	AAG03890.1
INSDC	AAG03890.1
NCBI Locus Tag	PA0501
protein_id(GenBank)	gb|AAG03890.1|AE004487_4|gnl|PseudoCAP|PA0501
TIGR	NTL03PA00502
UniParc	UPI00000C5091
UniProtKB Acc	Q9I617
UniProtKB ID	BIOF_PSEAE
UniRef100	UniRef100_Q9I617
UniRef50	UniRef50_B3PI88
UniRef90	UniRef90_Q9I617

Product

Feature Type	CDS
Coding Frame	1
Product Name	8-amino-7-oxononanoate synthase Product Name Confidence: Class 2
Synonyms	7-KAP synthetase, L-alanine--pimelyl coA ligase 7-keto-8-amino-pelargonic acid synthetase
Evidence for Translation
Charge (pH 7)	-7.16
Kyte-Doolittle Hydrophobicity Value	0.109
Molecular Weight (kDa)	42.2
Isoelectric Point (pI)	5.93

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 507 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000488 (534 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA0501 Search term: bioF Search term: 8-amino-7-oxononanoate synthase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000248924 glycine C-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:4188] E-value: 1.7e-63 Percent Identity: 39.6

References

The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon. Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J J Biol Chem 1988 Dec 25;263(36):19577-85 PubMed ID: 3058702

Characterisation of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl CoA condensing enzyme. Webster SP, Campopiano DJ, Alexeev D, Alexeeva M, Watt RM, Sawyer L, Baxter RL Biochem Soc Trans 1998 Aug;26(3):S268 PubMed ID: 9765987

The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme. Alexeev D, Alexeeva M, Baxter RL, Campopiano DJ, Webster SP, Sawyer L J Mol Biol 1998 Nov 27;284(2):401-19 PubMed ID: 9813126