Pseudomonas aeruginosa PAO1, PA0590 (apaH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0590
Name
apaH
Replicon chromosome
Genomic location 649307 - 650158 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249281.1
GI 15595787
Affymetrix PA0590_apaH_at
DNASU PaCD00006259
Entrez 880834
GenBank AAG03979.1
INSDC AAG03979.1
NCBI Locus Tag PA0590
protein_id(GenBank) gb|AAG03979.1|AE004495_3|gnl|PseudoCAP|PA0590
TIGR NTL03PA00591
UniParc UPI0000125BFE
UniProtKB Acc Q9I5U7
UniProtKB ID APAH_PSEAE
UniRef100 UniRef100_B7V4H6
UniRef50 UniRef50_Q4K4X3
UniRef90 UniRef90_B7V4H6

Product

Feature Type CDS
Coding Frame 1
Product Name
bis(5'-nucleosyl)-tetraphosphatase
Product Name Confidence: Class 2
Synonyms diadenosine tetraphosphatase
Evidence for Translation
Charge (pH 7) 0.72
Kyte-Doolittle Hydrophobicity Value -0.346
Molecular Weight (kDa) 32.0
Isoelectric Point (pI) 7.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 236 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000573 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0590
Search term: apaH

Human Homologs

References

Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12.
Guranowski A, Jakubowski H, Holler E
J Biol Chem 1983 Dec 25;258(24):14784-9
PubMed ID: 6317672