Pseudomonas aeruginosa PAO1, PA0743

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01692
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03446
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01692
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000103
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc VALDEG-PWY L-valine degradation I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PIRSF PIRSF000103 HIBADH IPR015815 3-hydroxyisobutyrate dehydrogenase-related 1 298 3.3E-83
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 162 1.51E-49
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 164 293 5.55E-41
FunFam G3DSA:3.40.50.720:FF:000071 2-hydroxy-3-oxopropionate reductase - - 1 164 1.8E-66
Gene3D G3DSA:3.40.50.720 - - - 1 163 1.9E-60
Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 3 162 4.4E-53
Gene3D G3DSA:1.10.1040.10 - IPR013328 6-phosphogluconate dehydrogenase, domain 2 164 298 7.5E-48
FunFam G3DSA:1.10.1040.10:FF:000006 3-hydroxyisobutyrate dehydrogenase - - 165 297 2.7E-52
Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase IPR029154 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain 165 291 1.4E-33
NCBIfam TIGR01692 JCVI: 3-hydroxyisobutyrate dehydrogenase IPR011548 3-hydroxyisobutyrate dehydrogenase 6 292 3.8E-124
PANTHER PTHR22981 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED - - 1 293 3.5E-115

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.