Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0766
|
Name |
mucD
|
Replicon | chromosome |
Genomic location | 833949 - 835373 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
RefSeq | NP_249457.1 |
GI | 15595963 |
Affymetrix | PA0766_mucD_at |
Entrez | 879207 |
GenBank | AAG04155.1 |
INSDC | AAG04155.1 |
NCBI Locus Tag | PA0766 |
protein_id(GenBank) | gb|AAG04155.1|AE004511_8|gnl|PseudoCAP|PA0766 |
TIGR | NTL03PA00767 |
UniParc | UPI00000D4255 |
UniProtKB Acc | G3XD20 |
UniProtKB ID | G3XD20_PSEAE |
UniRef100 | UniRef100_W0YL26 |
UniRef50 | UniRef50_A4XSC0 |
UniRef90 | UniRef90_A6VAL0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
serine protease MucD precursor
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (50.32 kDa, PMID:21751344)
Detected by MALDI-TOF/TOF (PMID:19333994).
|
Charge (pH 7) | 1.43 |
Kyte-Doolittle Hydrophobicity Value | -0.057 |
Molecular Weight (kDa) | 50.3 |
Isoelectric Point (pI) | 7.77 |
Individual Mappings | |
Additional evidence for subcellular localization |
Detected in a periplasmic protein preparation by spheroplasting by lysozyme and sucrose.(PMID:19333994)
|
Source 1 | |
Database | VFDB |
Category | Alginate regulation |
Evidence |
|
Host Organism | |
Notes | |
Reference |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 616 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000740 (535 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0766
Search term: mucD
Search term: serine protease MucD precursor
|
Ensembl
110, assembly
GRCh38.p14
|
HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476]
E-value:
9.9e-42
Percent Identity:
35.4
|
Ensembl
110, assembly
GRCh38.p14
|
HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476]
E-value:
9.9e-42
Percent Identity:
35.4
|
Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA.
Boucher JC, Martinez-Salazar J, Schurr MJ, Mudd MH, Yu H, Deretic V
J Bacteriol 1996 Jan;178(2):511-23
PubMed ID: 8550474
|
Pseudomonas aeruginosa MucD regulates the alginate pathway through activation of MucA degradation via MucP proteolytic activity.
Damron FH, Yu HD
J Bacteriol 2011 Jan;193(1):286-91
PubMed ID: 21036998
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
|