Pseudomonas aeruginosa PAO1, PA0771 (era)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0771
Name
era
Replicon chromosome
Genomic location 839407 - 840324 (+ strand)

Cross-References

RefSeq NP_249462.1
GI 15595968
Affymetrix PA0771_era_at
Entrez 879487
GenBank AAG04160.1
INSDC AAG04160.1
NCBI Locus Tag PA0771
protein_id(GenBank) gb|AAG04160.1|AE004512_3|gnl|PseudoCAP|PA0771
TIGR NTL03PA00772
UniParc UPI000012A0F9
UniProtKB Acc Q9XCX8
UniProtKB ID ERA_PSEAE
UniRef100 UniRef100_B7UYX1
UniRef50 UniRef50_A5UFI7
UniRef90 UniRef90_B7UYX1

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP-binding protein Era
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.88
Kyte-Doolittle Hydrophobicity Value -0.343
Molecular Weight (kDa) 34.5
Isoelectric Point (pI) 6.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 648 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000745 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0771
Search term: era

Human Homologs

References

A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins.
Ahnn J, March PE, Takiff HE, Inouye M
Proc Natl Acad Sci U S A 1986 Dec;83(23):8849-53
PubMed ID: 3097637
Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
Chen X, Court DL, Ji X
Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8396-401
PubMed ID: 10411886
Cloning and analysis of the rnc-era-recO operon from Pseudomonas aeruginosa.
Powell B, Peters HK 3rd, Nakamura Y, Court D
J Bacteriol 1999 Aug;181(16):5111-3
PubMed ID: 10438789