Pseudomonas aeruginosa PAO1, PA0844 (plcH)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0052051	obsolete interaction with host via protein secreted by type II secretion system	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	2120196	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	21562128	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	2496027	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	8282618	Reviewed by curator
Molecular Function	GO:0033188	sphingomyelin synthase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	12799377	Reviewed by curator
Biological Process	GO:0015628	protein secretion by the type II secretion system	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	11726509	Reviewed by curator
Molecular Function	GO:0034480	phosphatidylcholine phospholipase C activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	12410824	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	21562128	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	21041488	Reviewed by curator
Biological Process	GO:0044179	hemolysis in other organism	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	12410824	Reviewed by curator
Molecular Function	GO:0016298	lipase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	2120196	Reviewed by curator
Cellular Component	GO:0005615	extracellular space	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	19360133	Reviewed by curator
Cellular Component	GO:0005615	extracellular space	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	16484187	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	23667230	Reviewed by curator
Cellular Component	GO:0005615	extracellular space	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	9199466	Reviewed by curator
Biological Process	GO:0044179	hemolysis in other organism	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	23667230	Reviewed by curator
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	ISM Inferred from Sequence Model Term mapped from: InterPro:PTHR31956	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0034480	phosphatidylcholine phospholipase C activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR03396	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004629	phospholipase C activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF05506	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0016042	lipid catabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF05506	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00565	Ether lipid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00562	Inositol phosphate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00564	Glycerophospholipid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae02024	Quorum sensing	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Xcp type II secretion system		ECO:0000037 not_recorded
MetaCyc		2-arachidonoylglycerol biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		plasmalogen degradation	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
PseudoCAP		glycerolipid and sphingolipid metabolism		ECO:0000037 not_recorded
MetaCyc		plasmalogen biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.40.720.10	Alkaline Phosphatase, subunit A	IPR017850	Alkaline-phosphatase-like, core domain superfamily	42	199	2.7E-38
Pfam	PF04185	Phosphoesterase family	IPR007312	Phosphoesterase	51	436	4.0E-125
Pfam	PF05506	Bacterial phospholipase C, C-terminal domain	IPR008475	Bacterial phospholipase C, C-terminal domain	512	619	1.3E-15
PANTHER	PTHR31956	NON-SPECIFIC PHOSPHOLIPASE C4-RELATED	IPR007312	Phosphoesterase	11	476	1.3E-98
Gene3D	G3DSA:3.40.720.10	Alkaline Phosphatase, subunit A	IPR017850	Alkaline-phosphatase-like, core domain superfamily	241	485	1.2E-52
Pfam	PF05506	Bacterial phospholipase C, C-terminal domain	IPR008475	Bacterial phospholipase C, C-terminal domain	629	712	1.5E-16
NCBIfam	TIGR03396	JCVI: phospholipase C, phosphocholine-specific	IPR017767	Bacterial phospholipase C, phosphocholine-specific	8	725	0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.