Pseudomonas aeruginosa PAO1, PA0854 (fumC2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004333 fumarate hydratase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01362
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016829 lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF10415
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF48557
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006106 fumarate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01362
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006099 tricarboxylic acid cycle
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF10415
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0045239 tricarboxylic acid cycle enzyme complex
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01362
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc TCA TCA cycle I (prokaryotic) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Citrate cycle (TCA cycle) ECO:0000037
not_recorded
PseudoCyc GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ANARESP1-PWY anaerobic respiration 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc P22-PWY acetyl-CoA assimilation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc FERMENTATION-PWY mixed acid fermentation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00020 Citrate cycle (TCA cycle) 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd01362 Fumarase_classII IPR005677 Fumarate hydratase, class II 3 457 0.0
PRINTS PR00149 Fumarate lyase superfamily signature IPR000362 Fumarate lyase family 269 296 1.9E-32
PRINTS PR00145 Argininosuccinate lyase family signature - - 131 153 1.5E-6
PANTHER PTHR11444 ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE IPR005677 Fumarate hydratase, class II 2 460 0.0
FunFam G3DSA:1.20.200.10:FF:000001 Fumarate hydratase, mitochondrial - - 137 404 1.7E-117
Pfam PF10415 Fumarase C C-terminus IPR018951 Fumarase C, C-terminal 406 458 3.5E-26
PRINTS PR00149 Fumarate lyase superfamily signature IPR000362 Fumarate lyase family 132 150 1.9E-32
SUPERFAMILY SSF48557 L-aspartase-like IPR008948 L-Aspartase-like 3 459 0.0
FunFam G3DSA:1.10.275.10:FF:000001 Fumarate hydratase, mitochondrial - - 3 136 1.1E-59
NCBIfam TIGR00979 JCVI: class II fumarate hydratase IPR005677 Fumarate hydratase, class II 3 458 0.0
PRINTS PR00145 Argininosuccinate lyase family signature - - 315 331 1.5E-6
PRINTS PR00145 Argininosuccinate lyase family signature - - 173 193 1.5E-6
Gene3D G3DSA:1.20.200.10 Fumarase/aspartase (Central domain) - - 137 403 3.0E-96
Gene3D G3DSA:1.10.40.30 - - - 406 462 7.9E-28
Hamap MF_00743 Fumarate hydratase class II [fumC]. IPR005677 Fumarate hydratase, class II 2 460 89.637482
Pfam PF00206 Lyase IPR022761 Fumarate lyase, N-terminal 10 340 2.6E-107
PRINTS PR00149 Fumarate lyase superfamily signature IPR000362 Fumarate lyase family 178 196 1.9E-32
Gene3D G3DSA:1.10.275.10 - IPR024083 Fumarase/histidase, N-terminal 3 136 8.9E-63
FunFam G3DSA:1.10.40.30:FF:000002 Fumarate hydratase class II - - 405 461 3.2E-29
PRINTS PR00149 Fumarate lyase superfamily signature IPR000362 Fumarate lyase family 315 331 1.9E-32

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.