Pseudomonas aeruginosa PAO1, PA0887 (acsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004823 leucine-tRNA ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006090 pyruvate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019643 reductive tricarboxylic acid cycle
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0008152 metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044248 cellular catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0015976 carbon utilization
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019541 propionate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0003987 acetate-CoA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016208 AMP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019427 acetyl-CoA biosynthetic process from acetate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc ACETATEUTIL-PWY superpathway of acetate utilization and formation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00640 Propanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00680 Methane metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00010 Glycolysis / Gluconeogenesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Propanoate metabolism ECO:0000037
not_recorded
PseudoCAP Reductive carboxylate cycle (CO2 fixation) ECO:0000037
not_recorded
PseudoCyc PWY0-1313 acetate conversion to acetyl-CoA 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd05966 ACS - - 23 634 0.0
NCBIfam TIGR02188 JCVI: acetate--CoA ligase IPR011904 Acetate-CoA ligase 21 643 0.0
FunFam G3DSA:3.30.300.30:FF:000004 Acetyl-coenzyme A synthetase - - 518 649 2.8E-65
SUPERFAMILY SSF56801 Acetyl-CoA synthetase-like - - 17 642 0.0
Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain 24 81 2.7E-22
Pfam PF13193 AMP-binding enzyme C-terminal domain IPR025110 AMP-binding enzyme, C-terminal domain 531 609 7.5E-25
PANTHER PTHR24095 ACETYL-COENZYME A SYNTHETASE - - 19 646 0.0
Hamap MF_01123 Acetyl-coenzyme A synthetase [acs]. IPR011904 Acetate-CoA ligase 2 645 51.996025
Gene3D G3DSA:3.30.300.30 - IPR045851 AMP-binding enzyme, C-terminal domain superfamily 518 651 2.4E-33
FunFam G3DSA:3.40.50.12780:FF:000001 Acetyl-coenzyme A synthetase - - 5 517 0.0
Pfam PF00501 AMP-binding enzyme IPR000873 AMP-dependent synthetase/ligase domain 83 522 1.9E-93
Gene3D G3DSA:3.40.50.12780 - IPR042099 ANL, N-terminal domain 3 517 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.