Pseudomonas aeruginosa PAO1, PA0887 (acsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0887
Name
acsA
Replicon chromosome
Genomic location 969670 - 971625 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_249578.1
GI 15596084
Affymetrix PA0887_acsA_at
Entrez 879732
GenBank AAG04276.1
INSDC AAG04276.1
NCBI Locus Tag PA0887
protein_id(GenBank) gb|AAG04276.1|AE004523_4|gnl|PseudoCAP|PA0887
TIGR NTL03PA00888
UniParc UPI00000C51A9
UniProtKB Acc Q9I558
UniProtKB ID ACSA1_PSEAE
UniRef100 UniRef100_Q9I558
UniRef50 UniRef50_Q8ZKF6
UniRef90 UniRef90_Q9I558

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-coenzyme A synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.20
Kyte-Doolittle Hydrophobicity Value -0.214
Molecular Weight (kDa) 71.8
Isoelectric Point (pI) 6.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 585 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000854 (1033 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0887
Search term: acsA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814]
E-value: 9.1e-204
Percent Identity: 54.0

References

Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli.
Kumari S, Tishel R, Eisenbach M, Wolfe AJ
J. Bacteriol. 1995 May;177(10):2878-86
PubMed ID: 7751300