Pseudomonas aeruginosa PAO1, PA0904 (lysC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0008652 cellular amino acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00657
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004072 aspartate kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00656
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009089 lysine biosynthetic process via diaminopimelate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00656
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc THRESYN-PWY superpathway of L-threonine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc HOMOSERSYN-PWY L-homoserine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc DAPLYSINESYN-PWY L-lysine biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Lysine biosynthesis ECO:0000037
not_recorded
PseudoCyc P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00261 Monobactam biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00300 Lysine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR00656 JCVI: aspartate kinase, monofunctional class IPR005260 Aspartate kinase, monofunctional class 1 404 1.3E-130
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 332 405 4.37E-25
PANTHER PTHR21499 ASPARTATE KINASE - - 1 402 4.1E-116
FunFam G3DSA:3.30.2130.10:FF:000002 Aspartokinase - - 253 412 6.3E-74
CDD cd04913 ACT_AKii-LysC-BS-like_1 - - 263 337 1.83104E-29
PIRSF PIRSF000726 Asp_kin IPR005260 Aspartate kinase, monofunctional class 57 411 0.0
Pfam PF00696 Amino acid kinase family IPR001048 Aspartate/glutamate/uridylate kinase 3 229 6.1E-49
SUPERFAMILY SSF53633 Carbamate kinase-like IPR036393 Acetylglutamate kinase-like superfamily 4 241 1.31E-75
Gene3D G3DSA:3.30.2130.10 - - - 254 412 6.0E-70
PIRSF PIRSF000726 Asp_kin IPR005260 Aspartate kinase, monofunctional class 1 62 1.1E-23
Gene3D G3DSA:3.40.1160.10 - IPR036393 Acetylglutamate kinase-like superfamily 1 253 9.9E-110
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 249 327 1.4E-17
NCBIfam TIGR00657 JCVI: aspartate kinase IPR001341 Aspartate kinase 63 403 6.2E-117
CDD cd04923 ACT_AK-LysC-DapG-like_2 - - 342 404 3.33613E-31
Pfam PF13840 ACT domain IPR027795 CASTOR, ACT domain 339 399 1.3E-15
CDD cd04261 AAK_AKii-LysC-BS IPR041740 Aspartokinase catalytic domain 3 241 0.0
FunFam G3DSA:3.40.1160.10:FF:000002 Aspartokinase - - 1 254 4.4E-122
Pfam PF01842 ACT domain IPR002912 ACT domain 268 325 2.2E-10

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.