Pseudomonas aeruginosa PAO1, PA0991 (hptA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0991
Name
hptA
Replicon chromosome
Genomic location 1072462 - 1072839 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249682
GI 15596188
Affymetrix PA0991_at
DNASU PaCD00006457
GenBank AAG04380.1
protein_id(GenBank) gb|AAG04380.1|AE004532_4|gnl|PseudoCAP|PA0991
TIGR NTL03PA00992
UniProtKB Acc Q9I4X8
UniProtKB ID Q9I4X8_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
Histidine phosphotransfer protein HptA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.85
Kyte-Doolittle Hydrophobicity Value 0.045
Molecular Weight (kDa) 13.3
Isoelectric Point (pI) 4.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000954 (200 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0991
Search term: hptA

Human Homologs

References

Two-component systems in Pseudomonas aeruginosa: why so many?
Rodrigue A, Quentin Y, Lazdunski A, Méjean V, Foglino M
Trends Microbiol 2000 Nov;8(11):498-504
PubMed ID: 11121759