Pseudomonas aeruginosa PAO1, PA1003 (mvfR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Annotation Updates

Date Description Acknowledgements
Apr 14, 2003 New gene name: mvfR. Alt. Gene name: pqsR; New protein name: Transcriptional regulator; New genomic context: regulates phnAB operon (Old: regulates pqsABCDE operon); Added PMID: 11724939; Author Comments: “MvfR was previously demonstrated to be a transcriptional regulator controlling the expression of the phnAB operon (Cao et al.). To our understanding, Gallagher et al. did not show that MvfR regulates the so-called pqsABCDE genes, but only that PQS in not produced if this gene is inactivated (which we had previously reported in Cao et al.). We believe that it is unjustified and prematurate to change the name of mvfR for pqsR.” Eric Déziel, Laurence G. Rahme, Massachusetts General Hospital, Boston, MA, USA
Sep 5, 2006 New product name: Transcriptional regulator MvfR. (Existing value: Transcriptional regulator). New subcellular localization: Cytoplasmic Membrane (Existing value: Unknown). New subcellular localization confidence: Class 1 (Existing value: Class 3). New genomic context: MvfR controls the pqsABCDE and phnAB operons, which encode proteins mediating 4-hydroxy-2-alkylquinoline biosynthesis. New genomic context: MvfR dimer activates pqsA-E transcription by binding to a LysR box, TTCGGACTCCGAA, centred at -45 bp relative to the pqsA transcriptional initiation site. New evidence reference (PMID): 16735731. New evidence reference (PMID): 14739337. New evidence reference (PMID): 11724939. New evidence reference (PMID): 15686549. Literature review. Approved by reference author Laurence G. Rahme, Harvard University, USA.
Jan 2, 2003 New gene name: pqsR. New protein name confidence: 1 (Old: 3); New genomic context: “regulates pqsABCDE operon”; Added function: “Quinolone signal response”. New PubMed ID: 12426334. Raymond C. Lo and Fiona S.L. Brinkman, Simon Fraser University, Canada (based on literature review); approved by reference author Colin Manoil