Pseudomonas aeruginosa PAO1, PA1013 (purC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004357 glutamate-cysteine ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006163 purine nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00081
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009236 cobalamin biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01415
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00081
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6123 inosine-5'-phosphate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF01259 SAICAR synthetase IPR028923 SAICAR synthetase/ADE2, N-terminal 7 231 7.9E-65
FunFam G3DSA:3.30.200.20:FF:000086 Phosphoribosylaminoimidazole-succinocarboxamide synthase - - 6 94 1.5E-36
FunFam G3DSA:3.30.470.20:FF:000006 Phosphoribosylaminoimidazole-succinocarboxamide synthase - - 85 220 2.8E-63
NCBIfam TIGR00081 JCVI: phosphoribosylaminoimidazolesuccinocarboxamide synthase IPR001636 Phosphoribosylaminoimidazole-succinocarboxamide synthase 3 233 6.3E-79
Gene3D G3DSA:3.30.470.20 - - - 85 220 6.7E-98
Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 - - 6 231 6.7E-98
Hamap MF_00137 Phosphoribosylaminoimidazole-succinocarboxamide synthase [purC]. IPR028923 SAICAR synthetase/ADE2, N-terminal 4 234 31.412979
SUPERFAMILY SSF56104 SAICAR synthase-like - - 3 232 6.21E-80
PANTHER PTHR43599 MULTIFUNCTIONAL PROTEIN ADE2 - - 1 231 2.8E-45
CDD cd01415 SAICAR_synt_PurC IPR033934 Bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide synthase 7 233 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.