Pseudomonas aeruginosa PAO1, PA1080 (flgE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1080
Name
flgE
Replicon chromosome
Genomic location 1165882 - 1167270 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249771.1
GI 15596277
Affymetrix PA1080_flgE_at
Entrez 878285
GenBank AAG04469.1
INSDC AAG04469.1
NCBI Locus Tag PA1080
protein_id(GenBank) gb|AAG04469.1|AE004539_11|gnl|PseudoCAP|PA1080
TIGR NTL03PA01081
UniParc UPI00000C523D
UniProtKB Acc Q9I4P9
UniProtKB ID Q9I4P9_PSEAE
UniRef100 UniRef100_Q9I4P9
UniRef50 UniRef50_Q9I4P9
UniRef90 UniRef90_Q9I4P9

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar hook protein FlgE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (48.34 kDa, PMID:21751344)
Charge (pH 7) -10.52
Kyte-Doolittle Hydrophobicity Value -0.325
Molecular Weight (kDa) 48.3
Isoelectric Point (pI) 4.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 317 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001042 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1080
Search term: flgE

Human Homologs

References

Flagellar hook and hook-associated proteins of Salmonella typhimurium and their relationship to other axial components of the flagellum.
Homma M, DeRosier DJ, Macnab RM
J Mol Biol 1990 Jun 20;213(4):819-32
PubMed ID: 2193164
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344