Pseudomonas aeruginosa PAO1, PA1097 (fleQ)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:2000155	positive regulation of cilium-dependent cell motility	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	12218010	Reviewed by curator
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	22581773	Reviewed by curator
Biological Process	GO:0006355	regulation of transcription, DNA-templated	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	12218010	Reviewed by curator
Biological Process	GO:1901202	negative regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	18485075	Reviewed by curator
Biological Process	GO:1902021	regulation of bacterial-type flagellum-dependent cell motility	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	9287015	Reviewed by curator
Molecular Function	GO:0000976	transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0035438	cyclic-di-GMP binding Interaction partner: CHEBI:49537	IPI Inferred from Physical Interaction	ECO:0000353 physical interaction evidence used in manual assertion	24167275	Reviewed by curator
Molecular Function	GO:0035438	cyclic-di-GMP binding	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	18485075	Reviewed by curator
Biological Process	GO:0045785	positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	18485075	Reviewed by curator
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	9287015	Reviewed by curator
Biological Process	GO:1902021	regulation of bacterial-type flagellum-dependent cell motility	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	14617143	Reviewed by curator
Biological Process	GO:0006351	transcription, DNA-templated	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	9287015	Reviewed by curator
Molecular Function	GO:0001216	DNA-binding transcription activator activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	22581773	Reviewed by curator
Molecular Function	GO:0016887	ATPase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00382	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0008134	transcription factor binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00158	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006355	regulation of transcription, DNA-templated	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00158	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0005524	ATP binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00158	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0043565	sequence-specific DNA binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PR01590	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Motility & Attachment Other PAO1 genes in this class Transcriptional regulators Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae02025	Biofilm formation - Pseudomonas aeruginosa	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae02020	Two-component system	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:1.10.10.60	-	-	-	426	483	8.6E-12
SUPERFAMILY	SSF52172	CheY-like	IPR011006	CheY-like superfamily	3	188	8.08E-10
FunFam	G3DSA:3.40.50.300:FF:000006	DNA-binding transcriptional regulator NtrC	-	-	137	316	3.3E-83
PRINTS	PR01590	FIS bacterial regulatory protein HTH signature	IPR002197	DNA binding HTH domain, Fis-type	444	461	1.6E-8
SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	IPR027417	P-loop containing nucleoside triphosphate hydrolase	146	387	4.57E-71
SUPERFAMILY	SSF46689	Homeodomain-like	IPR009057	Homeobox-like domain superfamily	434	480	1.7E-9
Gene3D	G3DSA:3.40.50.2300	-	-	-	1	135	1.1E-63
Pfam	PF06490	Flagellar regulatory protein FleQ	IPR010518	Flagellar regulatory FleQ	6	123	1.3E-29
Pfam	PF00158	Sigma-54 interaction domain	IPR002078	RNA polymerase sigma factor 54 interaction domain	146	313	7.0E-76
Pfam	PF02954	Bacterial regulatory protein, Fis family	IPR002197	DNA binding HTH domain, Fis-type	438	478	1.0E-12
SMART	SM00382	AAA_5	IPR003593	AAA+ ATPase domain	166	310	8.6E-11
FunFam	G3DSA:1.10.8.60:FF:000037	Sigma-54-dependent Fis family transcriptional regulator	-	-	318	394	2.1E-51
FunFam	G3DSA:1.10.10.60:FF:000260	Fis family transcriptional regulator	-	-	412	483	1.1E-37
Gene3D	G3DSA:1.10.8.60	-	-	-	318	394	3.9E-22
PRINTS	PR01590	FIS bacterial regulatory protein HTH signature	IPR002197	DNA binding HTH domain, Fis-type	461	481	1.6E-8
CDD	cd00009	AAA	-	-	165	308	1.19689E-23
PANTHER	PTHR32071	TRANSCRIPTIONAL REGULATORY PROTEIN	-	-	5	484	0.0
Gene3D	G3DSA:3.40.50.300	-	IPR027417	P-loop containing nucleoside triphosphate hydrolase	136	317	1.5E-69

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.