Pseudomonas aeruginosa PAO1, PA1120 (tpbB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0052621 diguanylate cyclase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA14_49890
ECO:0000250
sequence similarity evidence used in manual assertion
19543378 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
IDA
Inferred from Direct Assay
ECO:0000005
enzyme assay evidence
16477007 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
19543378 Reviewed by curator
Cellular Component GO:0016021 integral component of membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00672
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00672
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Motility & Attachment Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class
Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02025 Biofilm formation - Pseudomonas aeruginosa 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00672 HAMP domain IPR003660 HAMP domain 181 232 5.1E-9
SUPERFAMILY SSF55073 IPR029787 Nucleotide cyclase 254 408 1.02E-44
Gene3D G3DSA:3.30.70.270 254 413 1.3E-54
SMART SM00267 IPR000160 GGDEF domain 238 411 2.0E-56
CDD cd01949 GGDEF IPR000160 GGDEF domain 250 406 4.71227E-60
ProSiteProfiles PS50887 GGDEF domain profile. IPR000160 GGDEF domain 279 415 31.828
SMART SM00304 IPR003660 HAMP domain 183 236 9.6E-8
TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain IPR000160 GGDEF domain 245 408 1.1E-44
MobiDBLite mobidb-lite consensus disorder prediction 413 429 -
Coils Coil 217 244 -
Pfam PF00990 Diguanylate cyclase, GGDEF domain IPR000160 GGDEF domain 249 405 8.0E-47
MobiDBLite mobidb-lite consensus disorder prediction 413 435 -
CDD cd06225 HAMP IPR003660 HAMP domain 185 232 8.10412E-5
ProSiteProfiles PS50885 HAMP domain profile. IPR003660 HAMP domain 183 236 9.764
Pfam PF17152 Periplasmic sensor domain IPR033417 Periplasmic sensor domain CHASE8 45 145 1.2E-33

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.