Pseudomonas aeruginosa PAO1, PA1249 (aprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0045959 negative regulation of complement activation, classical pathway
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 22131330 Reviewed by curator
Biological Process GO:0001869 negative regulation of complement activation, lectin pathway
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 22131330 Reviewed by curator
Molecular Function GO:0008233 peptidase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 22859302 Reviewed by curator
Biological Process GO:0009405 pathogenesis
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 22131330 Reviewed by curator
Biological Process GO:0010765 positive regulation of sodium ion transport
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 22859302 Reviewed by curator
Cellular Component GO:0005615 extracellular space
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08548
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008237 metallopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005509 calcium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08548
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Apr type I secretion system ECO:0000037
not_recorded
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00313 NodO calcium binding signature - - 369 377 3.9E-12
PRINTS PR00313 NodO calcium binding signature - - 339 350 3.9E-12
PRINTS PR00313 NodO calcium binding signature - - 378 387 3.9E-12
Pfam PF13583 Metallo-peptidase family M12B Reprolysin-like - - 170 230 1.8E-5
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 14 255 4.73E-71
PIRSF PIRSF001205 Serralysin IPR016294 Peptidase M10B 1 479 0.0
Pfam PF08548 Peptidase M10 serralysin C terminal IPR013858 Peptidase M10 serralysin, C-terminal 257 479 7.5E-82
Gene3D G3DSA:2.150.10.10 - IPR011049 Serralysin-like metalloprotease, C-terminal 21 476 0.0
Pfam PF00353 RTX calcium-binding nonapeptide repeat (4 copies) IPR001343 RTX calcium-binding nonapeptide repeat 350 384 1.1E-9
Gene3D G3DSA:3.40.390.10 Collagenase (Catalytic Domain) IPR024079 Metallopeptidase, catalytic domain superfamily 27 259 0.0
SUPERFAMILY SSF51120 beta-Roll IPR011049 Serralysin-like metalloprotease, C-terminal 256 478 6.41E-48
FunFam G3DSA:2.150.10.10:FF:000001 Serralysin - - 254 476 8.3E-118
PRINTS PR00313 NodO calcium binding signature - - 360 368 3.9E-12
NCBIfam NF035945 NCBIFAM: serralysin family metalloprotease - - 14 479 0.0
FunFam G3DSA:3.40.390.10:FF:000046 Serralysin - - 27 259 7.6E-120
SMART SM00235 col_5 IPR006026 Peptidase, metallopeptidase 78 241 2.0E-29
CDD cd04277 ZnMc_serralysin_like IPR034033 Serralysin-like metallopeptidase domain 65 256 7.4526E-46

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.