Pseudomonas aeruginosa PAO1, PA1277 (cobQ)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0051921	adenosylcobyric acid synthase (glutamine-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	1655697	Reviewed by curator
Biological Process	GO:0009236	cobalamin biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00028	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00028	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-5508	adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00860	Porphyrin and chlorophyll metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-5509	adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	P381-PWY	adenosylcobalamin biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCAP		Cobalamin biosynthesis		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	IPR027417	P-loop containing nucleoside triphosphate hydrolase	6	240	2.83E-58
PANTHER	PTHR21343	DETHIOBIOTIN SYNTHETASE	-	-	6	486	0.0
Gene3D	G3DSA:3.40.50.880	-	IPR029062	Class I glutamine amidotransferase-like	257	401	7.5E-16
Pfam	PF01656	CobQ/CobB/MinD/ParA nucleotide binding domain	IPR002586	CobQ/CobB/MinD/ParA nucleotide binding domain	8	233	4.1E-23
CDD	cd01750	GATase1_CobQ	IPR033949	Cobyric acid synthase, glutamine amidotransferase type 1	255	444	4.57272E-75
SUPERFAMILY	SSF52317	Class I glutamine amidotransferase-like	IPR029062	Class I glutamine amidotransferase-like	254	447	5.77E-42
NCBIfam	TIGR00313	JCVI: cobyric acid synthase CobQ	IPR004459	Cobyric acid synthase CobQ	8	478	0.0
Gene3D	G3DSA:3.40.50.300	-	IPR027417	P-loop containing nucleoside triphosphate hydrolase	3	244	5.6E-62
CDD	cd05389	CobQ_N	IPR047045	Cobyric acid synthase, N-terminal domain	6	228	0.0
Hamap	MF_00028	Cobyric acid synthase [cobQ].	IPR004459	Cobyric acid synthase CobQ	1	488	216.30957
Pfam	PF07685	CobB/CobQ-like glutamine amidotransferase domain	IPR011698	CobB/CobQ-like glutamine amidotransferase	254	437	6.9E-58

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.