Pseudomonas aeruginosa PAO1, PA1302 (hxuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1302
Name
hxuA
Synonym: hxuC
Replicon chromosome
Genomic location 1411585 - 1414140 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249993.1
GI 15596499
Affymetrix PA1302_at
Entrez 881567
GenBank AAG04691.1
INSDC AAG04691.1
NCBI Locus Tag PA1302
protein_id(GenBank) gb|AAG04691.1|AE004559_10|gnl|PseudoCAP|PA1302
TIGR NTL03PA01303
UniParc UPI00000C52FD
UniProtKB Acc Q9I442
UniProtKB ID Q9I442_PSEAE
UniRef100 UniRef100_A0A081HSQ1
UniRef50 UniRef50_E2XN42
UniRef90 UniRef90_A6V8Q8

Product

Feature Type CDS
Coding Frame 1
Product Name
HxuA
Product Name Confidence: Class 1
Synonyms Heme receptor HxuA
Evidence for Translation
Charge (pH 7) -2.21
Kyte-Doolittle Hydrophobicity Value -0.560
Molecular Weight (kDa) 95.2
Isoelectric Point (pI) 6.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 164 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001245 (371 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1302
Search term: hxuA
Search term: HxuA

Human Homologs

References

A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b.
Cope LD, Yogev R, Muller-Eberhard U, Hansen EJ
J Bacteriol 1995 May;177(10):2644-53
PubMed ID: 7751272
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM
Science 1995 Jul 28;269(5223):496-512
PubMed ID: 7542800
Cloning and characterization of tdhA, a locus encoding a TonB-dependent heme receptor from Haemophilus ducreyi.
Thomas CE, Olsen B, Elkins C
Infect Immun 1998 Sep;66(9):4254-62
PubMed ID: 9712775
Pseudomonas aeruginosa possesses three distinct systems for sensing and using the host molecule haem.
Otero-Asman JR, García-García AI, Civantos C, Quesada JM, Llamas MA
Environ Microbiol 2019 Dec;21(12):4629-4647
PubMed ID: 31390127