Pseudomonas aeruginosa PAO1, PA1326 (ilvA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006544 glycine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Molecular Function GO:0004609 phosphatidylserine decarboxylase activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006563 L-serine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006566 threonine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0009097 isoleucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004794 L-threonine ammonia-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ILEUSYN-PWY L-isoleucine biosynthesis I (from threonine) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
PseudoCyc BRANCHED-CHAIN-AA-SYN-PWY superpathway of branched amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 430 513 1.3E-25
PANTHER PTHR48078 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED - - 24 513 0.0
CDD cd04906 ACT_ThrD-I_1 - - 339 423 1.79659E-40
NCBIfam TIGR01124 JCVI: threonine ammonia-lyase, biosynthetic IPR005787 Threonine dehydratase, biosynthetic 16 513 0.0
FunFam G3DSA:3.40.50.1100:FF:000008 L-threonine dehydratase - - 141 311 6.1E-70
Pfam PF00291 Pyridoxal-phosphate dependent enzyme IPR001926 Tryptophan synthase beta chain-like, PALP domain 30 317 1.1E-81
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 421 513 2.75E-27
CDD cd04907 ACT_ThrD-I_2 - - 434 513 2.46795E-44
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 330 420 2.8E-22
CDD cd01562 Thr-dehyd - - 17 321 0.0
Gene3D G3DSA:3.40.50.1100 - IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 32 311 2.9E-111
Gene3D G3DSA:3.40.1020.10 Biosynthetic Threonine Deaminase; Domain 3 IPR038110 Threonine dehydratase, ACT-like domain superfamily 339 514 1.2E-71
Gene3D G3DSA:3.40.50.1100 - IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 65 156 2.9E-111
FunFam G3DSA:3.40.1020.10:FF:000001 L-threonine dehydratase - - 339 515 9.0E-75
SUPERFAMILY SSF53686 Tryptophan synthase beta subunit-like PLP-dependent enzymes IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 16 366 1.7E-103

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.