Pseudomonas aeruginosa PAO1, PA1326 (ilvA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004609 phosphatidylserine decarboxylase activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006563 L-serine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006544 glycine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006566 threonine metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0009097 isoleucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0030170 pyridoxal phosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00165
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004794 L-threonine ammonia-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006520 cellular amino acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00165
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
PseudoCyc ILEUSYN-PWY L-isoleucine biosynthesis I (from threonine) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc BRANCHED-CHAIN-AA-SYN-PWY superpathway of branched amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00291 Pyridoxal-phosphate dependent enzyme IPR001926 Pyridoxal-phosphate dependent enzyme 30 317 1.2E-81
SUPERFAMILY SSF55021 421 513 2.75E-27
Gene3D G3DSA:3.40.50.1100 61 157 0.0
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 330 420 9.5E-24
Gene3D G3DSA:3.40.1020.10 IPR038110 Threonine dehydratase, ACT-like domain superfamily 339 515 2.4E-72
SUPERFAMILY SSF53686 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme 16 366 1.7E-103
ProSiteProfiles PS51672 ACT-like domain profile. IPR001721 Threonine dehydratase, ACT-like domain 435 506 18.362
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 430 513 2.7E-25
CDD cd04907 ACT_ThrD-I_2 434 513 2.03687E-44
CDD cd01562 Thr-dehyd 17 321 6.16967E-157
CDD cd04906 ACT_ThrD-I_1 339 423 1.48278E-40
ProSiteProfiles PS51672 ACT-like domain profile. IPR001721 Threonine dehydratase, ACT-like domain 340 412 13.585
TIGRFAM TIGR01124 ilvA_2Cterm: threonine ammonia-lyase, biosynthetic IPR005787 Threonine dehydratase, biosynthetic 16 513 0.0
ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site 53 66 -
Gene3D G3DSA:3.40.50.1100 25 328 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.