Pseudomonas aeruginosa PAO1, PA1430 (lasR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006355 regulation of transcription, DNA-templated
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
1902216 Reviewed by curator
Biological Process GO:0009405 pathogenesis
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
8454322 Reviewed by curator
Biological Process GO:0051544 positive regulation of elastin biosynthetic process
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
1902216 Reviewed by curator
Molecular Function GO:0003700 DNA-binding transcription factor activity
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
1902216 Reviewed by curator
Biological Process GO:0060310 regulation of elastin catabolic process
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
1902216 Reviewed by curator
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF46894
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00196
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Transcriptional regulators Other PAO1 genes in this class
Adaptation, Protection Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae02025 Biofilm formation - Pseudomonas aeruginosa 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00038 LuxR bacterial regulatory protein HTH signature IPR000792 Transcription regulator LuxR, C-terminal 207 219 1.7E-5
SUPERFAMILY SSF75516 Pheromone-binding domain of LuxR-like quorum-sensing transcription factors IPR036693 Transcription factor LuxR-like, autoinducer-binding domain superfamily 9 160 2.62E-36
Pfam PF00196 Bacterial regulatory proteins, luxR family IPR000792 Transcription regulator LuxR, C-terminal 176 231 2.9E-22
CDD cd06170 LuxR_C_like IPR000792 Transcription regulator LuxR, C-terminal 177 233 5.85301E-20
PANTHER PTHR44688 - - - 55 236 5.8E-21
Gene3D G3DSA:1.10.10.10 - IPR036388 Winged helix-like DNA-binding domain superfamily 176 237 7.8E-17
PRINTS PR00038 LuxR bacterial regulatory protein HTH signature IPR000792 Transcription regulator LuxR, C-terminal 177 191 1.7E-5
Gene3D G3DSA:3.30.450.80 - IPR036693 Transcription factor LuxR-like, autoinducer-binding domain superfamily 1 173 5.4E-56
PRINTS PR00038 LuxR bacterial regulatory protein HTH signature IPR000792 Transcription regulator LuxR, C-terminal 191 207 1.7E-5
SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators IPR016032 Signal transduction response regulator, C-terminal effector 170 237 7.82E-16
SMART SM00421 luxrmega5 IPR000792 Transcription regulator LuxR, C-terminal 174 231 5.2E-19
Pfam PF03472 Autoinducer binding domain IPR005143 Transcription factor LuxR-like, autoinducer-binding domain 18 160 1.2E-37

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.