Pseudomonas aeruginosa PAO1, PA1455 (fliA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1455
Name
fliA
Synonym: rpoF
Replicon chromosome
Genomic location 1584795 - 1585538 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250146.1
GI 15596652
Affymetrix PA1455_fliA_at
DNASU PaCD00006666
Entrez 881996
GenBank AAG04844.1
INSDC AAG04844.1
NCBI Locus Tag PA1455
protein_id(GenBank) gb|AAG04844.1|AE004575_3|gnl|PseudoCAP|PA1455
TIGR NTL03PA01456
UniParc UPI000012A975
UniProtKB Acc P29248
UniProtKB ID FLIA_PSEAE
UniRef100 UniRef100_P29248
UniRef50 UniRef50_P29248
UniRef90 UniRef90_P29248

Product

Feature Type CDS
Coding Frame 1
Product Name
sigma factor FliA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.34
Kyte-Doolittle Hydrophobicity Value -0.395
Molecular Weight (kDa) 27.5
Isoelectric Point (pI) 5.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 577 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001370 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1455
Search term: fliA
Search term: sigma factor FliA

Human Homologs

References

The fliA (rpoF) gene of Pseudomonas aeruginosa encodes an alternative sigma factor required for flagellin synthesis.
Starnbach MN, Lory S
Mol Microbiol 1992 Feb;6(4):459-69
PubMed ID: 1560774