Pseudomonas aeruginosa PAO1, PA1460 (motC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1460
Name
motC
Synonym: motA
Replicon chromosome
Genomic location 1590533 - 1591273 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentMotC-MotD require MotY for optimal function. MotCD and MotY are necessary for movement in viscous environments and over surfaces.

Cross-References

RefSeq NP_250151.1
GI 15596657
Affymetrix PA1460_at
DNASU PaCD00006670
Entrez 882162
GenBank AAG04849.1
INSDC AAG04849.1
NCBI Locus Tag PA1460
protein_id(GenBank) gb|AAG04849.1|AE004575_8|gnl|PseudoCAP|PA1460
TIGR NTL03PA01461
UniParc UPI00000D427D
UniProtKB Acc G3XD73
UniProtKB ID G3XD73_PSEAE
UniRef100 UniRef100_W0YR22
UniRef50 UniRef50_B7UW92
UniRef90 UniRef90_B7UW92

Product

Feature Type CDS
Coding Frame 1
Product Name
MotC
Product Name Confidence: Class 3
Synonyms MotA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.52
Kyte-Doolittle Hydrophobicity Value 0.517
Molecular Weight (kDa) 26.0
Isoelectric Point (pI) 4.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 302 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001375 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1460
Search term: motC
Search term: MotC

Human Homologs

References

The complex flagellar torque generator of Pseudomonas aeruginosa.
Doyle TB, Hawkins AC, McCarter LL
J Bacteriol 2004 Oct;186(19):6341-50
PubMed ID: 15375113
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
An operon of Bacillus subtilis motility genes transcribed by the sigma D form of RNA polymerase.
Mirel DB, Lustre VM, Chamberlin MJ
J Bacteriol 1992 Jul;174(13):4197-204
PubMed ID: 1624413