Pseudomonas aeruginosa PAO1, PA4397 (panE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0008677 2-dehydropantoate 2-reductase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 9721324 Reviewed by curator
Biological Process GO:0015940 pantothenate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00745
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008677 2-dehydropantoate 2-reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00745
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PANTOSYN-PWY pantothenate and coenzyme A biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PANTO-PWY phosphopantothenate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Pantothenate and CoA biosynthesis ECO:0000037
not_recorded
KEGG pae00770 Pantothenate and CoA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:1.10.1040.10 - IPR013328 6-phosphogluconate dehydrogenase, domain 2 174 296 5.5E-39
Gene3D G3DSA:3.40.50.720 - - - 1 173 2.5E-34
Pfam PF08546 Ketopantoate reductase PanE/ApbA C terminal IPR013752 Ketopantoate reductase, C-terminal domain 174 292 8.3E-30
NCBIfam TIGR00745 JCVI: 2-dehydropantoate 2-reductase IPR003710 Ketopantoate reductase ApbA/PanE 2 296 9.6E-86
Pfam PF02558 Ketopantoate reductase PanE/ApbA IPR013332 Ketopantoate reductase, N-terminal domain 3 149 1.2E-34
PANTHER PTHR43765 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED - - 1 292 7.5E-66
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 174 293 4.42E-32
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 168 2.3E-30

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.