Pseudomonas aeruginosa PAO1, PA5493 (polA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006260 DNA replication
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
4890764 Reviewed by curator
Molecular Function GO:0003677 DNA binding
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P00582
ECO:0000250
sequence similarity evidence used in manual assertion
4890764 Reviewed by curator
Biological Process GO:0090305 nucleic acid phosphodiester bond hydrolysis
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
4890764 Reviewed by curator
Molecular Function GO:0008408 3'-5' exonuclease activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
4890764 Reviewed by curator
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
13563462 Reviewed by curator
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006139 nucleobase-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00474
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003676 nucleic acid binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.420.10
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00476
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008408 3'-5' exonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00474
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00476
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006261 DNA-dependent DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00868
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae03420 Nucleotide excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae03440 Homologous recombination 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae03030 DNA replication 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.40.50.1010:FF:000001 DNA polymerase I - - 1 169 1.7E-70
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 739 764 1.0E-77
SMART SM00475 53exo3 IPR002421 5'-3' exonuclease 4 266 2.6E-114
NCBIfam TIGR00593 JCVI: DNA polymerase I IPR018320 DNA polymerase 1 6 913 0.0
SUPERFAMILY SSF47807 5' to 3' exonuclease, C-terminal subdomain IPR036279 5'-3' exonuclease, C-terminal domain superfamily 168 288 1.14E-28
SMART SM00279 HhH_4 IPR008918 Helix-hairpin-helix motif, class 2 170 205 6.1E-12
CDD cd09859 PIN_53EXO - - 8 164 9.97775E-78
Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal 6 167 1.7E-51
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 715 728 1.0E-77
FunFam G3DSA:3.30.420.10:FF:000026 DNA polymerase I - - 309 526 1.3E-97
Gene3D G3DSA:3.30.70.370 - - - 649 909 7.5E-115
CDD cd09898 H3TH_53EXO IPR020045 DNA polymerase I-like, H3TH domain 170 250 1.39424E-24
SMART SM00482 polaultra3 IPR001098 DNA-directed DNA polymerase, family A, palm domain 671 877 1.5E-118
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 640 662 1.0E-77
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 830 846 1.0E-77
Gene3D G3DSA:1.20.1060.10 Taq DNA Polymerase; Chain T, domain 4 - - 527 643 1.1E-36
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 860 873 1.0E-77
SUPERFAMILY SSF56672 DNA/RNA polymerases IPR043502 DNA/RNA polymerase superfamily 506 913 0.0
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 663 678 1.0E-77
Pfam PF01612 3'-5' exonuclease IPR002562 3'-5' exonuclease domain 313 501 1.0E-37
CDD cd08637 DNA_pol_A_pol_I_C - - 532 910 0.0
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 685 708 1.0E-77
FunFam G3DSA:1.10.150.20:FF:000002 DNA polymerase I - - 694 837 1.9E-60
FunFam G3DSA:1.10.150.20:FF:000003 DNA polymerase I - - 170 265 8.2E-27
Gene3D G3DSA:3.40.50.1010 - - - 1 169 1.2E-53
SUPERFAMILY SSF53098 Ribonuclease H-like IPR012337 Ribonuclease H-like superfamily 311 501 3.8E-55
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 776 787 1.0E-77
SUPERFAMILY SSF88723 PIN domain-like IPR029060 PIN-like domain superfamily 5 167 2.44E-52
Gene3D G3DSA:1.10.150.20 - - - 694 837 7.5E-115
Gene3D G3DSA:3.30.420.10 - IPR036397 Ribonuclease H superfamily 309 526 9.9E-74
PANTHER PTHR10133 DNA POLYMERASE I IPR002298 DNA polymerase A 308 913 0.0
CDD cd06139 DNA_polA_I_Ecoli_like_exo - - 327 523 6.20375E-98
SMART SM00474 35exoneu6 IPR002562 3'-5' exonuclease domain 312 501 1.1E-36
Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold IPR020045 DNA polymerase I-like, H3TH domain 168 269 4.5E-27
Gene3D G3DSA:1.10.150.20 - - - 170 264 8.2E-26
Pfam PF00476 DNA polymerase family A IPR001098 DNA-directed DNA polymerase, family A, palm domain 538 911 0.0
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 798 809 1.0E-77
FunFam G3DSA:1.20.1060.10:FF:000001 DNA polymerase I - - 527 643 2.9E-40

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.