Pseudomonas aeruginosa PAO1, PA5522 (pauA6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5522
Name
pauA6
Replicon chromosome
Genomic location 6214434 - 6215801 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_254209.1
GI 15600715
Affymetrix PA5522_at
Entrez 877956
GenBank AAG08907.1
INSDC AAG08907.1
NCBI Locus Tag PA5522
protein_id(GenBank) gb|AAG08907.1|AE004964_10|gnl|PseudoCAP|PA5522
TIGR NTL03PA05523
UniParc UPI00000C6051
UniProtKB Acc Q9HT51
UniProtKB ID Q9HT51_PSEAE
UniRef100 UniRef100_W0Z3Z2
UniRef50 UniRef50_G8PYH4
UniRef90 UniRef90_A6VEZ9

Product

Feature Type CDS
Coding Frame 1
Product Name
Glutamylpolyamine synthetase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.04
Kyte-Doolittle Hydrophobicity Value -0.178
Molecular Weight (kDa) 49.9
Isoelectric Point (pI) 5.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 625 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003799 (810 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5522
Search term: pauA6

Human Homologs

Ensembl 110, assembly GRCh38.p14
lengsin, lens protein with glutamine synthetase domain [Source:HGNC Symbol;Acc:HGNC:21016]
E-value: 6.2e-17
Percent Identity: 25.1

References

Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750