Pseudomonas aeruginosa PAO1, PA0004 (gyrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006265 DNA topological change
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
6327603 Reviewed by curator
Molecular Function GO:0005524 ATP binding
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
9756859 Reviewed by curator
Molecular Function GO:0003677 DNA binding
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
6294616 Reviewed by curator
Biological Process GO:0042493 response to drug
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
9144789 Reviewed by curator
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
368801 Reviewed by curator
Biological Process GO:0006351 transcription, DNA-templated
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
15535863 Reviewed by curator
Cellular Component GO:0005694 chromosome
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01898
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006265 DNA topological change
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.50.670
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.50.670
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.50.670
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.50.670
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other PAO1 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Hamap MF_01898 DNA gyrase subunit B [gyrB]. IPR011557 DNA gyrase, subunit B 4 806 101.230545
CDD cd16928 HATPase_GyrB-like - - 38 217 3.79656E-105
NCBIfam TIGR01059 JCVI: DNA gyrase subunit B IPR011557 DNA gyrase, subunit B 7 806 0.0
PRINTS PR00418 DNA topoisomerase II family signature - - 489 505 9.7E-72
PRINTS PR00418 DNA topoisomerase II family signature - - 738 754 9.7E-72
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 314 330 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 376 396 1.8E-83
PRINTS PR00418 DNA topoisomerase II family signature - - 507 524 9.7E-72
FunFam G3DSA:3.30.230.10:FF:000005 DNA gyrase subunit B - - 221 394 4.0E-77
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 362 376 1.8E-83
Pfam PF00204 DNA gyrase B IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 222 392 9.2E-57
PRINTS PR00418 DNA topoisomerase II family signature - - 115 129 9.7E-72
FunFam G3DSA:3.40.50.670:FF:000005 DNA gyrase subunit B - - 393 593 6.3E-124
PRINTS PR00418 DNA topoisomerase II family signature - - 270 283 9.7E-72
PRINTS PR00418 DNA topoisomerase II family signature - - 72 85 9.7E-72
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 4 221 1.1E-94
SUPERFAMILY SSF56719 Type II DNA topoisomerase IPR013760 DNA topoisomerase, type IIA-like domain superfamily 396 796 2.59E-88
Pfam PF18053 DNA gyrase B subunit insert domain IPR041423 DNA gyrase subunit B insert domain 566 732 2.3E-51
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 221 243 1.8E-83
CDD cd00822 TopoII_Trans_DNA_gyrase - - 221 379 3.86198E-75
FunFam G3DSA:3.40.50.670:FF:000004 DNA gyrase subunit B - - 706 805 1.4E-48
Pfam PF00986 DNA gyrase B subunit, carboxyl terminus IPR002288 DNA gyrase B subunit, C-terminal 734 795 8.2E-31
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 197 210 1.8E-83
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 33 177 2.5E-30
Gene3D G3DSA:3.40.50.670 - IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal 705 806 1.5E-28
FunFam G3DSA:3.30.565.10:FF:000002 DNA gyrase subunit B - - 4 220 3.9E-96
PRINTS PR00418 DNA topoisomerase II family signature - - 422 436 9.7E-72
PRINTS PR00418 DNA topoisomerase II family signature - - 37 52 9.7E-72
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 182 197 1.8E-83
Gene3D G3DSA:3.40.50.670 - IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal 399 591 2.1E-75
SMART SM00433 topII5 IPR001241 DNA topoisomerase, type IIA 37 799 0.0
FunFam G3DSA:3.10.20.690:FF:000002 DNA gyrase subunit B - - 595 684 1.1E-43
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 244 262 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 775 791 1.8E-83
PRINTS PR00418 DNA topoisomerase II family signature - - 527 539 9.7E-72
SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like IPR020568 Ribosomal protein uS5 domain 2-type superfamily 222 394 2.85E-57
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 34 176 2.3E-22
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 472 481 1.8E-83
PANTHER PTHR45866 DNA GYRASE/TOPOISOMERASE SUBUNIT B - - 3 805 0.0
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 759 771 1.8E-83
PRINTS PR01159 DNA gyrase subunit B signature IPR000565 DNA topoisomerase, type IIA, subunit B 7 17 1.8E-83
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 7 219 5.24E-75
Gene3D G3DSA:3.10.20.690 - - - 595 684 1.5E-26
Gene3D G3DSA:3.30.230.10 - IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup 222 398 4.5E-66
Pfam PF01751 Toprim domain IPR006171 TOPRIM domain 421 533 1.4E-17
CDD cd03366 TOPRIM_TopoIIA_GyrB IPR034160 DNA gyrase subunit B, TOPRIM domain 420 534 1.34844E-79

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.