Pseudomonas aeruginosa UCBPP-PA14, PA14_48060 (aprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0005509 calcium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005615 extracellular space
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008237 metallopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00235
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Secreted Factors (toxins, enzymes, alginate) Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00313 NodO calcium binding signature - - 369 377 3.9E-12
Pfam PF13583 Metallo-peptidase family M12B Reprolysin-like - - 170 230 1.8E-5
FunFam G3DSA:2.150.10.10:FF:000001 Serralysin - - 254 476 1.2E-117
NCBIfam NF035945 NCBIFAM: serralysin family metalloprotease - - 14 479 0.0
Pfam PF00353 RTX calcium-binding nonapeptide repeat (4 copies) IPR001343 RTX calcium-binding nonapeptide repeat 350 384 1.1E-9
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 14 255 7.58E-71
SUPERFAMILY SSF51120 beta-Roll IPR011049 Serralysin-like metalloprotease, C-terminal 256 478 4.32E-48
Pfam PF08548 Peptidase M10 serralysin C terminal IPR013858 Peptidase M10 serralysin, C-terminal 257 479 1.1E-81
PRINTS PR00313 NodO calcium binding signature - - 378 387 3.9E-12
PIRSF PIRSF001205 Serralysin IPR016294 Peptidase M10B 1 479 0.0
CDD cd04277 ZnMc_serralysin_like IPR034033 Serralysin-like metallopeptidase domain 65 256 1.61901E-45
Gene3D G3DSA:2.150.10.10 - IPR011049 Serralysin-like metalloprotease, C-terminal 21 476 0.0
PRINTS PR00313 NodO calcium binding signature - - 339 350 3.9E-12
PRINTS PR00313 NodO calcium binding signature - - 360 368 3.9E-12
FunFam G3DSA:3.40.390.10:FF:000046 Serralysin - - 27 259 5.8E-120
Gene3D G3DSA:3.40.390.10 Collagenase (Catalytic Domain) IPR024079 Metallopeptidase, catalytic domain superfamily 27 259 0.0
SMART SM00235 col_5 IPR006026 Peptidase, metallopeptidase 78 241 4.9E-29

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.