Pseudomonas aeruginosa UCBPP-PA14, PA14_50200 (fleS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0000160 phosphorelay signal transduction system
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA1098
 ECO:0000249
sequence similarity evidence used in automatic assertion		 7591148
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Two-component System  ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd00082 HisKA IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 179 243 1.70335E-11
CDD cd00130 PAS IPR000014 PAS domain 84 145 1.66035E-5
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 377 390 1.5E-15
SUPERFAMILY SSF55785 PYP-like sensor domain (PAS domain) IPR035965 PAS domain superfamily 75 153 4.01E-10
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 287 393 3.8E-28
SMART SM00091 pas_2 IPR000014 PAS domain 75 138 3.2E-7
PANTHER PTHR43065 SENSOR HISTIDINE KINASE - - 43 395 2.4E-42
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 251 394 1.31E-33
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 353 371 1.5E-15
CDD cd00075 HATPase - - 296 389 1.95221E-23
SUPERFAMILY SSF47384 Homodimeric domain of signal transducing histidine kinase IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily 175 245 2.75E-12
FunFam G3DSA:3.30.565.10:FF:000116 Sensor histidine kinase FleS - - 255 395 1.5E-85
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 324 338 1.5E-15
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 342 352 1.5E-15
SMART SM00388 HisKA_10 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 181 247 3.0E-14
Pfam PF00512 His Kinase A (phospho-acceptor) domain IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 181 245 1.2E-11
Gene3D G3DSA:1.10.287.130 - - - 166 244 2.4E-15
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 255 395 1.6E-34
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 291 391 3.7E-22
FunFam G3DSA:1.10.287.130:FF:000059 PAS domain-containing sensor histidine kinase - - 166 244 5.5E-49
Gene3D G3DSA:3.30.450.20 PAS domain - - 60 161 4.9E-6
Pfam PF13188 PAS domain IPR000014 PAS domain 76 131 3.0E-6

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.