Pseudomonas aeruginosa UCBPP-PA14, PA14_57390 (murF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0071555 cell wall organization
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_02019
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_02019
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_02019
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016881 acid-amino acid ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08245
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009058 biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08245
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00550 Peptidoglycan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00300 Lysine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01502 Vancomycin resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR01143 JCVI: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 30 450 0.0
Hamap MF_02019 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [murF]. IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 5 451 33.89389
Gene3D G3DSA:3.40.1190.10 - IPR036565 Mur-like, catalytic domain superfamily 83 317 7.8E-75
Gene3D G3DSA:3.90.190.20 - IPR036615 Mur ligase, C-terminal domain superfamily 319 451 1.2E-43
SUPERFAMILY SSF63418 MurE/MurF N-terminal domain IPR035911 MurE/MurF, N-terminal 5 98 7.19E-25
Gene3D G3DSA:3.40.1390.10 - - - 1 82 7.7E-28
PANTHER PTHR43024 UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE - - 6 456 0.0
SUPERFAMILY SSF53244 MurD-like peptide ligases, peptide-binding domain IPR036615 Mur ligase, C-terminal domain superfamily 320 450 5.26E-34
Pfam PF08245 Mur ligase middle domain IPR013221 Mur ligase, central 108 300 4.1E-47
Pfam PF01225 Mur ligase family, catalytic domain IPR000713 Mur ligase, N-terminal catalytic domain 26 93 9.9E-9
Pfam PF02875 Mur ligase family, glutamate ligase domain IPR004101 Mur ligase, C-terminal 320 391 2.7E-12
SUPERFAMILY SSF53623 MurD-like peptide ligases, catalytic domain IPR036565 Mur-like, catalytic domain superfamily 103 318 6.02E-53

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.