Pseudomonas aeruginosa PAO1, PA0122 (rahU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0122
Name
rahU
Replicon chromosome
Genomic location 141917 - 142327 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_248812.1
GI 15595320
Affymetrix PA0122_at
DNASU PaCD00006054
Entrez 880611
GenBank AAG03512.1
INSDC AAG03512.1
NCBI Locus Tag PA0122
protein_id(GenBank) gb|AAG03512.1|AE004450_7|gnl|PseudoCAP|PA0122
TIGR NTL03PA00123
UniParc UPI00000C4F4A
UniProtKB Acc Q9I710
UniProtKB ID Q9I710_PSEAE
UniRef100 UniRef100_W0YKT2
UniRef50 UniRef50_A6UXQ8
UniRef90 UniRef90_W0YKT2

Product

Feature Type CDS
Coding Frame 1
Product Name
rahU
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.08
Kyte-Doolittle Hydrophobicity Value -0.386
Molecular Weight (kDa) 14.6
Isoelectric Point (pI) 4.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000120 (304 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0122
Search term: rahU
Search term: rahU

References

Cloning and nucleotide sequence of cDNA encoding Asp-hemolysin from Aspergillus fumigatus.
Ebina K, Sakagami H, Yokota K, Kondo H
Biochim. Biophys. Acta 1994 Sep;1219(1):148-50
PubMed ID: 8086452
Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa.
Rao J, DiGiandomenico A, Artamonov M, Leitinger N, Amin AR, Goldberg JB
Cell. Immunol. 2011 ;270(2):95-102
PubMed ID: 21679933
RahU: an inducible and functionally pleiotropic protein in Pseudomonas aeruginosa modulates innate immunity and inflammation in host cells.
Rao J, Elliott MR, Leitinger N, Jensen RV, Goldberg JB, Amin AR
Cell. Immunol. 2011 ;270(2):103-13
PubMed ID: 21704311
A novel oxidized low-density lipoprotein-binding protein from Pseudomonas aeruginosa.
Rao J, DiGiandomenico A, Unger J, Bao Y, Polanowska-Grabowska RK, Goldberg JB
Microbiology (Reading, Engl.) 2008 Feb;154(Pt 2):654-65
PubMed ID: 18227268