Pseudomonas aeruginosa PAO1, PA0366 (laoC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0366
Name
laoC
Replicon chromosome
Genomic location 409504 - 410934 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentPart of the Lao (long-chain-alcohol/aldehyde-oxidation) gene cluster (laoABC).

Cross-References

RefSeq NP_249057.1
GI 15595563
Affymetrix PA0366_at
Entrez 880299
GenBank AAG03755.1
INSDC AAG03755.1
NCBI Locus Tag PA0366
protein_id(GenBank) gb|AAG03755.1|AE004474_7|gnl|PseudoCAP|PA0366
TIGR NTL03PA00367
UniParc UPI0000126E3F
UniProtKB Acc Q9I6C8
UniProtKB ID CALB_PSEAE
UniRef100 UniRef100_Q9I6C8
UniRef50 UniRef50_Q9I6C8
UniRef90 UniRef90_Q9I6C8

Product

Feature Type CDS
Coding Frame 1
Product Name
LaoC
Product Name Confidence: Class 1
Synonyms probable aldehyde dehydrogenase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 7.35
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 52.9
Isoelectric Point (pI) 9.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 593 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000357 (539 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0366
Search term: laoC
Search term: LaoC

Human Homologs

Ensembl 94, assembly GRCh38.p12
aldehyde dehydrogenase 3 family member A2 [Source:HGNC Symbol;Acc:HGNC:403]
E-value: 7.8e-80
Percent Identity: 38.7

References

Purification and characterization of the coniferyl aldehyde dehydrogenase from Pseudomonas sp. Strain HR199 and molecular characterization of the gene.
Achterholt S, Priefert H, Steinbüchel A
J. Bacteriol. 1998 Sep;180(17):4387-91
PubMed ID: 9721273
PubMed ID: 29678916