Pseudomonas aeruginosa PAO1, PA0373 (ftsY)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0373
Name
ftsY
Replicon chromosome
Genomic location 417527 - 418894 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_249064.1
GI 15595570
Affymetrix PA0373_ftsY_at
Entrez 883018
GenBank AAG03762.1
INSDC AAG03762.1
NCBI Locus Tag PA0373
protein_id(GenBank) gb|AAG03762.1|AE004475_4|gnl|PseudoCAP|PA0373
TIGR NTL03PA00374
UniParc UPI00000C5031
UniProtKB Acc Q9I6C1
UniProtKB ID Q9I6C1_PSEAE
UniRef100 UniRef100_Q9I6C1
UniRef50 UniRef50_Q4K4B8
UniRef90 UniRef90_S0JE80

Product

Feature Type CDS
Coding Frame 1
Product Name
signal recognition particle receptor FtsY
Product Name Confidence: Class 2
Synonyms cell division protein FtsY
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -19.99
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 48.4
Isoelectric Point (pI) 4.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 663 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000364 (548 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0373
Search term: ftsY

Human Homologs

Ensembl 94, assembly GRCh38.p12
SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307]
E-value: 2.9e-23
Percent Identity: 34.1

References

The identification of the Escherichia coli ftsY gene product: an unusual protein.
Gill DR, Salmond GP
Mol. Microbiol. 1990 Apr;4(4):575-83
PubMed ID: 2161989
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.
Luirink J, ten Hagen-Jongman CM, van der Weijden CC, Oudega B, High S, Dobberstein B, Kusters R
EMBO J. 1994 May;13(10):2289-96
PubMed ID: 8194520
Crystal structure of the NG domain from the signal-recognition particle receptor FtsY.
Montoya G, Svensson C, Luirink J, Sinning I
Nature 1997 Jan;385(6614):365-8
PubMed ID: 9002525