Pseudomonas aeruginosa PAO1, PA0393 (proC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0393
Name
proC
Replicon chromosome
Genomic location 434830 - 435651 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249084.1
GI 15595590
Affymetrix PA0393_proC_at
Entrez 878413
GenBank AAG03782.1
NCBI Locus Tag PA0393
protein_id(GenBank) gb|AAG03782.1|AE004476_12|gnl|PseudoCAP|PA0393
TIGR NTL03PA00394
UniProtKB Acc P22008
UniProtKB ID P5CR_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
pyrroline-5-carboxylate reductase
Product Name Confidence: Class 1
Synonyms delta-1-pyrroline-5-carboxylate reductase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.12
Kyte-Doolittle Hydrophobicity Value 0.184
Molecular Weight (kDa) 28.1
Isoelectric Point (pI) 4.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 591 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000384 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0393
Search term: proC

Human Homologs

Ensembl 94, assembly GRCh38.p12
pyrroline-5-carboxylate reductase 1 [Source:HGNC Symbol;Acc:HGNC:9721]
E-value: 1.3e-34
Percent Identity: 37.4

References

Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.
Savioz A, Jeenes DJ, Kocher HP, Haas D
Gene 1990 Jan;86(1):107-11
PubMed ID: 2107123
Characterisation of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria.
Whitchurch CB, Hobbs M, Livingston SP, Krishnapillai V, Mattick JS
Gene 1991 May;101(1):33-44
PubMed ID: 1676385