Pseudomonas aeruginosa PAO1, PA0594 (surA)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 652480 - 653772 (- strand)


RefSeq NP_249285.1
GI 15595791
Affymetrix PA0594_surA_at
Entrez 879552
GenBank AAG03983.1
INSDC AAG03983.1
NCBI Locus Tag PA0594
protein_id(GenBank) gb|AAG03983.1|AE004495_7|gnl|PseudoCAP|PA0594
UniParc UPI0000EAE04F
UniProtKB Acc Q9I5U3
UniRef100 UniRef100_Q9I5U3
UniRef50 UniRef50_Q4K4X7
UniRef90 UniRef90_Q9I5U3


Feature Type CDS
Coding Frame 1
Product Name
peptidyl-prolyl cis-trans isomerase SurA
Product Name Confidence: Class 2
Synonyms Survival protein SurA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Detected using LC-MS/MS (46.95 kDa, PMID:21751344)
Charge (pH 7) -5.58
Kyte-Doolittle Hydrophobicity Value -0.446
Molecular Weight (kDa) 48.4
Isoelectric Point (pI) 5.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Outer Membrane Vesicle Class 1
Periplasmic Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 422 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000577 (553 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0594
Search term: surA


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
SurA assists the folding of Escherichia coli outer membrane proteins.
Lazar SW, Kolter R
J. Bacteriol. 1996 Mar;178(6):1770-3
PubMed ID: 8626309
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH.
Missiakas D, Betton JM, Raina S
Mol. Microbiol. 1996 Aug;21(4):871-84
PubMed ID: 8878048
A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli.
Dartigalongue C, Raina S
EMBO J. 1998 Jul;17(14):3968-80
PubMed ID: 9670013
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344