Pseudomonas aeruginosa PAO1, PA0607 (rpe)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0607
Name
rpe
Synonym: dod
Replicon chromosome
Genomic location 669415 - 670089 (+ strand)

Cross-References

RefSeq NP_249298.1
GI 15595804
Affymetrix PA0607_rpe_at
Entrez 878162
GenBank AAG03996.1
INSDC AAG03996.1
NCBI Locus Tag PA0607
protein_id(GenBank) gb|AAG03996.1|AE004497_3|gnl|PseudoCAP|PA0607
TIGR NTL03PA00608
UniParc UPI00000C50D7
UniProtKB Acc Q9I5T1
UniProtKB ID Q9I5T1_PSEAE
UniRef100 UniRef100_W0YMA3
UniRef50 UniRef50_P40117
UniRef90 UniRef90_Q88A31

Product

Feature Type CDS
Coding Frame 1
Product Name
ribulose-phosphate 3-epimerase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.38
Kyte-Doolittle Hydrophobicity Value 0.208
Molecular Weight (kDa) 24.1
Isoelectric Point (pI) 5.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7U5Y ISOMERASE 03/02/22 Crystal structure of ribulose-phosphate 3-epimerase from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.55 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 594 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000590 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0607
Search term: rpe

Human Homologs

Ensembl 110, assembly GRCh38.p14
ribulose-5-phosphate-3-epimerase [Source:HGNC Symbol;Acc:HGNC:10293]
E-value: 4.1e-38
Percent Identity: 39.1

References

Characterization of three genes in the dam-containing operon of Escherichia coli.
Lyngstadaas A, Løbner-Olesen A, Boye E
Mol Gen Genet 1995 Jun 10;247(5):546-54
PubMed ID: 7603433
Involvement of the ribulosephosphate epimerase gene in the dnaA and dnaR functions for initiation of chromosome replication in Escherichia coli.
Sakakibara Y
Mol Microbiol 1997 May;24(4):793-801
PubMed ID: 9194706
Impaired growth of an Escherichia coli rpe mutant lacking ribulose-5-phosphate epimerase activity.
Lyngstadaas A, Sprenger GA, Boye E
Biochim Biophys Acta 1998 Aug 24;1381(3):319-30
PubMed ID: 9729441