Pseudomonas aeruginosa PAO1, PA0688 (lapA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0688
Name
lapA
Replicon chromosome
Genomic location 747470 - 748576 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentThis gene is strongly induced under phosphate limiting conditions

Cross-References

RefSeq NP_249379.1
GI 15595885
Affymetrix PA0688_at
Entrez 880790
GenBank AAG04077.1
INSDC AAG04077.1
NCBI Locus Tag PA0688
protein_id(GenBank) gb|AAG04077.1|AE004504_1|gnl|PseudoCAP|PA0688
TIGR NTL03PA00689
UniParc UPI0000132001
UniProtKB Acc P35482
UniProtKB ID PPBL_PSEAE
UniRef100 UniRef100_P35482
UniRef50 UniRef50_P35482
UniRef90 UniRef90_P35482

Product

Feature Type CDS
Coding Frame 1
Product Name
low-molecular-weight alkaline phosphatase A, LapA
Product Name Confidence: Class 1
Synonyms probable binding protein component of ABC transporter
Evidence for Translation
Charge (pH 7) 7.82
Kyte-Doolittle Hydrophobicity Value -0.001
Molecular Weight (kDa) 37.9
Isoelectric Point (pI) 9.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 1
sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 173 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000667 (401 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0688
Search term: lapA

References

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.
Lewenza S, Falsafi RK, Winsor G, Gooderham WJ, McPhee JB, Brinkman FS, Hancock RE
Genome Res. 2005 Apr;15(4):583-9
PubMed ID: 15805499
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Type II-dependent secretion of a Pseudomonas aeruginosa DING protein.
Ball G, Viarre V, Garvis S, Voulhoux R, Filloux A
Res. Microbiol. 2012 Jul;163(6-7):457-69
PubMed ID: 22835944