Pseudomonas aeruginosa PAO1, PA0688 (lapA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0688
Name
lapA
Replicon chromosome
Genomic location 747470 - 748576 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentThis gene is strongly induced under phosphate limiting conditions

Cross-References

RefSeq NP_249379.1
GI 15595885
Affymetrix PA0688_at
Entrez 880790
GenBank AAG04077.1
INSDC AAG04077.1
NCBI Locus Tag PA0688
protein_id(GenBank) gb|AAG04077.1|AE004504_1|gnl|PseudoCAP|PA0688
TIGR NTL03PA00689
UniParc UPI0000132001
UniProtKB Acc P35482
UniProtKB ID PPBL_PSEAE
UniRef100 UniRef100_P35482
UniRef50 UniRef50_P35482
UniRef90 UniRef90_P35482

Product

Feature Type CDS
Coding Frame 1
Product Name
low-molecular-weight alkaline phosphatase A, LapA
Product Name Confidence: Class 1
Synonyms probable binding protein component of ABC transporter
Evidence for Translation
Charge (pH 7) 7.82
Kyte-Doolittle Hydrophobicity Value -0.001
Molecular Weight (kDa) 37.9
Isoelectric Point (pI) 9.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence
Extracellular Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 173 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000667 (401 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0688
Search term: lapA

References

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.
Lewenza S, Falsafi RK, Winsor G, Gooderham WJ, McPhee JB, Brinkman FS, Hancock RE
Genome Res. 2005 Apr;15(4):583-9
PubMed ID: 15805499
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Type II-dependent secretion of a Pseudomonas aeruginosa DING protein.
Ball G, Viarre V, Garvis S, Voulhoux R, Filloux A
Res. Microbiol. 2012 Jul;163(6-7):457-69
PubMed ID: 22835944