Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0905
|
Name |
rsmA
Synonym: csrA |
Replicon | chromosome |
Genomic location | 991013 - 991198 (+ strand) |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | Post-transcriptional riboregulator |
RefSeq | NP_249596.1 |
GI | 15596102 |
Affymetrix | PA0905_csrA_at |
DNASU | PaCD00006416 |
Entrez | 878352 |
GenBank | AAG04294.1 |
INSDC | AAG04294.1 |
NCBI Locus Tag | PA0905 |
protein_id(GenBank) | gb|AAG04294.1|AE004525_2|gnl|PseudoCAP|PA0905 |
TIGR | NTL03PA00906 |
UniParc | UPI00001285B6 |
UniProtKB Acc | O69078 |
UniProtKB ID | CSRA_PSEAE |
UniRef100 | UniRef100_B7UY29 |
UniRef50 | UniRef50_Q5E7G3 |
UniRef90 | UniRef90_A4VJB5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RsmA
|
Synonyms |
carbon storage regulator |
Evidence for Translation | |
Charge (pH 7) | 0.46 |
Kyte-Doolittle Hydrophobicity Value | -0.446 |
Molecular Weight (kDa) | 6.9 |
Isoelectric Point (pI) | 7.70 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
rsmA | rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. [PMID:16622241, PMID:11673439] | ARO:3005069 | protein homolog model | Perfect | 117.1 | 100.0 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7YR6 | RNA BINDING PROTEIN/RNA | 08/09/22 | Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with two RsmA protein dimers | Pseudomonas aeruginosa | 4.8 | ELECTRON MICROSCOPY | 100.0 |
7YR7 | RNA BINDING PROTEIN/RNA | 08/09/22 | Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with three RsmA protein dimers | Pseudomonas aeruginosa | 3.8 | ELECTRON MICROSCOPY | 100.0 |
1VPZ | RNA BINDING PROTEIN | 11/24/04 | Crystal structure of a putative carbon storage regulator protein (csra, pa0905) from pseudomonas aeruginosa at 2.05 A resolution | Pseudomonas aeruginosa | 2.05 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | PseudoCAP |
Category | RsmA |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | |
Infection model | Mouse model of chronic infection |
Infection model | Mouse model of acute pneumonia |
Reference | 18025099 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 227 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000872 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0905
Search term: rsmA
Search term: RsmA
|
Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1.
Heurlier K, Williams F, Heeb S, Dormond C, Pessi G, Singer D, Cámara M, Williams P, Haas D
J Bacteriol 2004 May;186(10):2936-45
PubMed ID: 15126453
|
The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa.
Pessi G, Williams F, Hindle Z, Heurlier K, Holden MT, Cámara M, Haas D, Williams P
J Bacteriol 2001 Nov;183(22):6676-83
PubMed ID: 11673439
|
Identification and molecular characterization of csrA, a pleiotropic gene from Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface properties.
Romeo T, Gong M, Liu MY, Brun-Zinkernagel AM
J Bacteriol 1993 Aug;175(15):4744-55
PubMed ID: 8393005
|
The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli.
Liu MY, Gui G, Wei B, Preston JF 3rd, Oakford L, Yüksel U, Giedroc DP, Romeo T
J Biol Chem 1997 Jul 11;272(28):17502-10
PubMed ID: 9211896
|
Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY.
O'Callaghan J, Reen FJ, Adams C, O'Gara F
Microbiology (Reading) 2011 Dec;157(Pt 12):3417-3428
PubMed ID: 21873408
|
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
|