Pseudomonas aeruginosa PAO1, PA0965 (ruvC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0965
Name
ruvC
Replicon chromosome
Genomic location 1051132 - 1051656 (+ strand)

Cross-References

RefSeq NP_249656.1
GI 15596162
Affymetrix PA0965_ruvC_at
Entrez 882131
GenBank AAG04354.1
INSDC AAG04354.1
NCBI Locus Tag PA0965
protein_id(GenBank) gb|AAG04354.1|AE004530_7|gnl|PseudoCAP|PA0965
TIGR NTL03PA00966
UniParc UPI00001353B3
UniProtKB Acc Q51424
UniProtKB ID RUVC_PSEAE
UniRef100 UniRef100_B7UXW7
UniRef50 UniRef50_Q87Y33
UniRef90 UniRef90_A6VA07

Product

Feature Type CDS
Coding Frame 1
Product Name
Holliday junction resolvase RuvC
Product Name Confidence: Class 1
Synonyms crossover junction endodeoxyribonuclease RuvC
Evidence for Translation
Charge (pH 7) 8.58
Kyte-Doolittle Hydrophobicity Value 0.051
Molecular Weight (kDa) 18.6
Isoelectric Point (pI) 10.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6LW3 DNA BINDING PROTEIN 02/07/20 Crystal structure of RuvC from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.38 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 537 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000930 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0965
Search term: ruvC

Human Homologs

References

Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli.
Ariyoshi M, Vassylyev DG, Iwasaki H, Nakamura H, Shinagawa H, Morikawa K
Cell 1994 Sep 23;78(6):1063-72
PubMed ID: 7923356
Molecular analysis of the Pseudomonas aeruginosa genes, ruvA, ruvB and ruvC, involved in processing of homologous recombination intermediates.
Hishida T, Iwasaki H, Ishioka K, Shinagawa H
Gene 1996 Dec 5;182(1-2):63-70
PubMed ID: 8982068