Pseudomonas aeruginosa PAO1, PA1099 (fleR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1099
Name
fleR
Replicon chromosome
Genomic location 1190385 - 1191806 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249790.1
GI 15596296
Affymetrix PA1099_fleR_at
Entrez 882087
GenBank AAG04488.1
INSDC AAG04488.1
NCBI Locus Tag PA1099
protein_id(GenBank) gb|AAG04488.1|AE004540_8|gnl|PseudoCAP|PA1099
TIGR NTL03PA01100
UniParc UPI00000C5249
UniProtKB Acc Q9I4N3
UniProtKB ID Q9I4N3_PSEAE
UniRef100 UniRef100_Q9I4N3
UniRef50 UniRef50_Q9I4N3
UniRef90 UniRef90_Q9I4N3

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.14
Kyte-Doolittle Hydrophobicity Value -0.017
Molecular Weight (kDa) 51.2
Isoelectric Point (pI) 6.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001060 (509 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1099
Search term: fleR

References

Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin.
Ritchings BW, Almira EC, Lory S, Ramphal R
Infect. Immun. 1995 Dec;63(12):4868-76
PubMed ID: 7591148