Pseudomonas aeruginosa PAO1, PA1157

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1157
Name
Replicon chromosome
Genomic location 1255042 - 1255752 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249848.1
GI 15596354
Affymetrix PA1157_at
DNASU PaCD00006531
Entrez 879028
GenBank AAG04546.1
INSDC AAG04546.1
NCBI Locus Tag PA1157
protein_id(GenBank) gb|AAG04546.1|AE004546_1|gnl|PseudoCAP|PA1157
TIGR NTL03PA01158
UniParc UPI00000C527B
UniProtKB Acc Q9I4I0
UniProtKB ID Q9I4I0_PSEAE
UniRef100 UniRef100_W0YL57
UniRef50 UniRef50_I7B3X2
UniRef90 UniRef90_W0YL57

Product

Feature Type CDS
Coding Frame 1
Product Name
probable two-component response regulator
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.81
Kyte-Doolittle Hydrophobicity Value -0.147
Molecular Weight (kDa) 26.4
Isoelectric Point (pI) 4.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database Victors : 4224
Category Not available / Not known
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Rattus norvegicus
Notes
Infection model Rat agar bead model of chronic lung infection
Reference 14641575

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 624 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001116 (506 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1157

Human Homologs

References

Primary characterization of the protein products of the Escherichia coli ompB locus: structure and regulation of synthesis of the OmpR and EnvZ proteins.
Comeau DE, Ikenaka K, Tsung KL, Inouye M
J Bacteriol 1985 Nov;164(2):578-84
PubMed ID: 2997120