Pseudomonas aeruginosa PAO1, PA1222

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1222
Name
Synonym: mltA
Replicon chromosome
Genomic location 1324793 - 1325950 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249913.1
GI 15596419
Affymetrix PA1222_at
DNASU PaCD00006566
Entrez 878372
GenBank AAG04611.1
INSDC AAG04611.1
NCBI Locus Tag PA1222
protein_id(GenBank) gb|AAG04611.1|AE004552_1|gnl|PseudoCAP|PA1222
TIGR NTL03PA01223
UniParc UPI00000C52B7
UniProtKB Acc Q9I4B6
UniProtKB ID Q9I4B6_PSEAE
UniRef100 UniRef100_Q9I4B6
UniRef50 UniRef50_Q4K4I3
UniRef90 UniRef90_Q02J58

Product

Feature Type CDS
Coding Frame 1
Product Name
probable membrane-bound lytic murein transglycolase A
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.15
Kyte-Doolittle Hydrophobicity Value -0.265
Molecular Weight (kDa) 41.9
Isoelectric Point (pI) 5.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 195 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001178 (501 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1222

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli.
Ursinus A, Höltje JV
J. Bacteriol. 1994 Jan;176(2):338-43
PubMed ID: 8288527
Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli.
Lommatzsch J, Templin MF, Kraft AR, Vollmer W, Höltje JV
J. Bacteriol. 1997 Sep;179(17):5465-70
PubMed ID: 9287002