Pseudomonas aeruginosa PAO1, PA1292

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1292
Name
Replicon chromosome
Genomic location 1402981 - 1403835 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249983.1
GI 15596489
Affymetrix PA1292_at
DNASU PaCD00006595
Entrez 881495
GenBank AAG04681.1
INSDC AAG04681.1
NCBI Locus Tag PA1292
protein_id(GenBank) gb|AAG04681.1|AE004558_10|gnl|PseudoCAP|PA1292
TIGR NTL03PA01293
UniParc UPI0000136F11
UniProtKB Acc Q9I452
UniProtKB ID THTM_PSEAE
UniRef100 UniRef100_Q9I452
UniRef50 UniRef50_Q9I452
UniRef90 UniRef90_Q9I452

Product

Feature Type CDS
Coding Frame 1
Product Name
probable 3-mercaptopyruvate sulfurtransferase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.44
Kyte-Doolittle Hydrophobicity Value -0.132
Molecular Weight (kDa) 30.6
Isoelectric Point (pI) 5.31

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 383 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001236 (539 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1292

Human Homologs

Ensembl 94, assembly GRCh38.p12
mercaptopyruvate sulfurtransferase [Source:HGNC Symbol;Acc:HGNC:7223]
E-value: 6.2e-32
Percent Identity: 36.2

References

Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis.
Nagahara N, Okazaki T, Nishino T
J. Biol. Chem. 1995 Jul;270(27):16230-5
PubMed ID: 7608189
Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis.
Nagahara N, Nishino T
J. Biol. Chem. 1996 Nov;271(44):27395-401
PubMed ID: 8910318