Pseudomonas aeruginosa PAO1, PA1423 (bdlA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1423
Name
bdlA
Synonym: bdlA
Synonym: biofilm dispersion locus A
Replicon chromosome
Genomic location 1548334 - 1549587 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentDeletion of bdlA impairs nutrient-induced dispersion

Cross-References

RefSeq NP_250114.1
GI 15596620
Affymetrix PA1423_at
Entrez 881734
GenBank AAG04812.1
INSDC AAG04812.1
NCBI Locus Tag PA1423
protein_id(GenBank) gb|AAG04812.1|AE004571_11|gnl|PseudoCAP|PA1423
TIGR NTL03PA01424
UniParc UPI00000C5374
UniProtKB Acc Q9I3S1
UniProtKB ID BDLA_PSEAE
UniRef100 UniRef100_Q9I3S1
UniRef50 UniRef50_Q9I3S1
UniRef90 UniRef90_Q9I3S1

Product

Feature Type CDS
Coding Frame 1
Product Name
BdlA
Product Name Confidence: Class 1
Synonyms BdlA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.18
Kyte-Doolittle Hydrophobicity Value -0.566
Molecular Weight (kDa) 46.9
Isoelectric Point (pI) 6.39

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 24901523
Source 2
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse model of acute pneumonia
Reference 24901523

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 427 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001343 (542 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1423
Search term: bdlA
Search term: BdlA

References

Characterization of the acc operon from the nopaline-type Ti plasmid pTiC58, which encodes utilization of agrocinopines A and B and susceptibility to agrocin 84.
Kim H, Farrand SK
J. Bacteriol. 1997 Dec;179(23):7559-72
PubMed ID: 9393724
BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa.
Morgan R, Kohn S, Hwang SH, Hassett DJ, Sauer K
J. Bacteriol. 2006 Nov;188(21):7335-43
PubMed ID: 17050921
The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes.
He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG
Proc. Natl. Acad. Sci. U.S.A. 2004 Feb;101(8):2530-5
PubMed ID: 14983043