Pseudomonas aeruginosa PAO1, PA1423 (bdlA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA1423
Name	bdlA Synonym: bdlA Synonym: biofilm dispersion locus A
Replicon	chromosome
Genomic location	1548334 - 1549587 (- strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs
Comment	Deletion of bdlA impairs nutrient-induced dispersion

Cross-References

RefSeq	NP_250114.1
GI	15596620
Affymetrix	PA1423_at
Entrez	881734
GenBank	AAG04812.1
INSDC	AAG04812.1
NCBI Locus Tag	PA1423
protein_id(GenBank)	gb|AAG04812.1|AE004571_11|gnl|PseudoCAP|PA1423
TIGR	NTL03PA01424
UniParc	UPI00000C5374
UniProtKB Acc	Q9I3S1
UniProtKB ID	BDLA_PSEAE
UniRef100	UniRef100_Q9I3S1
UniRef50	UniRef50_Q9I3S1
UniRef90	UniRef90_Q9I3S1

Product

Feature Type	CDS
Coding Frame	1
Product Name	BdlA Product Name Confidence: Class 1
Synonyms	BdlA
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-4.18
Kyte-Doolittle Hydrophobicity Value	-0.566
Molecular Weight (kDa)	46.9
Isoelectric Point (pI)	6.39

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	PseudoCAP
Category	Not available / Not known
Evidence	ECO:0000315 mutant phenotype evidence used in manual assertion
Host Organism	Arabidopsis thaliana
Notes
Infection model	Arabidopsis leaf infiltration model
Reference	24901523
Source 2
Database	PseudoCAP
Category	Not available / Not known
Evidence	ECO:0000315 mutant phenotype evidence used in manual assertion
Host Organism	Mus musculus
Notes
Infection model	Mouse model of acute pneumonia
Reference	24901523

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 427 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001343 (526 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA1423 Search term: bdlA Search term: BdlA

Human Homologs

References

Characterization of the acc operon from the nopaline-type Ti plasmid pTiC58, which encodes utilization of agrocinopines A and B and susceptibility to agrocin 84. Kim H, Farrand SK J Bacteriol 1997 Dec;179(23):7559-72 PubMed ID: 9393724

BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa. Morgan R, Kohn S, Hwang SH, Hassett DJ, Sauer K J Bacteriol 2006 Nov;188(21):7335-43 PubMed ID: 17050921

The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG Proc Natl Acad Sci U S A 2004 Feb 24;101(8):2530-5 PubMed ID: 14983043