Pseudomonas aeruginosa PAO1, PA1448 (fliR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1448
Name
fliR
Replicon chromosome
Genomic location 1575559 - 1576335 (+ strand)

Cross-References

RefSeq NP_250139.1
GI 15596645
Affymetrix PA1448_fliR_at
Entrez 881861
GenBank AAG04837.1
INSDC AAG04837.1
NCBI Locus Tag PA1448
protein_id(GenBank) gb|AAG04837.1|AE004574_8|gnl|PseudoCAP|PA1448
TIGR NTL03PA01449
UniParc UPI00000C5386
UniProtKB Acc Q9I3Q3
UniProtKB ID Q9I3Q3_PSEAE
UniRef100 UniRef100_Q9I3Q3
UniRef50 UniRef50_Q9I3Q3
UniRef90 UniRef90_Q9I3Q3

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar biosynthetic protein FliR
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -0.32
Kyte-Doolittle Hydrophobicity Value 1.201
Molecular Weight (kDa) 27.5
Isoelectric Point (pI) 6.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Flagellar
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 322 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001365 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1448
Search term: fliR

Human Homologs

References

Components of the Salmonella flagellar export apparatus and classification of export substrates.
Minamino T, Macnab RM
J Bacteriol 1999 Mar;181(5):1388-94
PubMed ID: 10049367
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular characterization, nucleotide sequence, and expression of the fliO, fliP, fliQ, and fliR genes of Escherichia coli.
Malakooti J, Ely B, Matsumura P
J Bacteriol 1994 Jan;176(1):189-97
PubMed ID: 8282695
A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.
Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T
DNA Res 1996 Dec 31;3(6):379-92
PubMed ID: 9097040