Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_05530
|
Name |
mexA
|
Replicon | chromosome |
Genomic location | 486775 - 487926 (+ strand) |
Transposon Mutants | 1 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | YP_788599.1 |
GI | 116054156 |
Entrez | 4384293 |
INSDC | ABJ15392.1 |
NCBI Locus Tag | PA14_05530 |
UniParc | UPI000012F021 |
UniProtKB Acc | Q02TY7 |
UniProtKB ID | Q02TY7_PSEAB |
UniRef100 | UniRef100_P52477 |
UniRef50 | UniRef50_P52477 |
UniRef90 | UniRef90_P52477 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RND multidrug efflux membrane fusion protein MexA
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 3.22 |
Kyte-Doolittle Hydrophobicity Value | -0.229 |
Molecular Weight (kDa) | 41.0 |
Isoelectric Point (pI) | 9.15 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexA | MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. [PMID:15117957] | ARO:3000377 | protein homolog model | Perfect | 716.1 | 100.0 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6TA6 | ANTIMICROBIAL PROTEIN | 10/29/19 | MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs | Pseudomonas aeruginosa | 3.2 | ELECTRON MICROSCOPY | 100.0 |
1T5E | TRANSPORT PROTEIN | 05/04/04 | The structure of MexA | Pseudomonas aeruginosa | 3 | X-RAY DIFFRACTION | 100.0 |
6TA5 | ANTIMICROBIAL PROTEIN | 10/29/19 | OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs | Pseudomonas aeruginosa | 3.2 | ELECTRON MICROSCOPY | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
Glycerin | DB09462 | DrugBank | 5.1.4 | P52477 | Multidrug resistance protein MexA | 100.0 | 383 | 2.9e-204 |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Caenorhabditis elegans |
Notes | |
Infection model | C. elegans fast killing model |
Reference | 9989496 |
Source 2 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Arabidopsis thaliana |
Notes | |
Infection model | Arabidopsis leaf infiltration model |
Reference | 9989496 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 394 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000416 (526 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_05530
Search term: mexA
Search term: RND multidrug efflux membrane fusion protein MexA
|