Pseudomonas aeruginosa UCBPP-PA14, PA14_08780 (rpoC)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_08780
Name	rpoC
Replicon	chromosome
Genomic location	750342 - 754541 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq	YP_788850.1
GI	116052304
EC Number	2.7.7.6
Entrez	4381344
INSDC	ABJ13540.1
NCBI Locus Tag	PA14_08780
UniParc	UPI000013473C
UniProtKB Acc	Q02T86
UniProtKB ID	RPOC_PSEAB
UniRef100	UniRef100_Q02T86
UniRef50	UniRef50_A7ZUK2
UniRef90	UniRef90_Q4K527

Product

Feature Type	CDS
Coding Frame	1
Product Name	DNA-directed RNA polymerase subunit beta'
Synonyms
Evidence for Translation
Charge (pH 7)	1.02
Kyte-Doolittle Hydrophobicity Value	-0.230
Molecular Weight (kDa)	154.4
Isoelectric Point (pI)	7.09

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
7VF9	TRANSCRIPTION	09/10/21	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes	Pseudomonas aeruginosa PAO1	4.04	ELECTRON MICROSCOPY	99.9
7XL3	TRANSCRIPTION	04/21/22	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (open lobe)	Pseudomonas aeruginosa PAO1	3.13	ELECTRON MICROSCOPY	99.9
7XYB	TRANSCRIPTION	06/01/22	The cryo-EM structure of an AlpA-loaded complex	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	3.7	ELECTRON MICROSCOPY	100.0
7XL4	TRANSCRIPTION	04/21/22	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (closed lobe)	Pseudomonas aeruginosa PAO1	3.86	ELECTRON MICROSCOPY	99.9
7F0R	TRANSCRIPTION/DNA	06/06/21	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT	5.8	ELECTRON MICROSCOPY	99.9
7XYA	TRANSCRIPTION	06/01/22	The cryo-EM structure of an AlpA-loading complex	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	3.3	ELECTRON MICROSCOPY	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 667 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001442 (533 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_08780 Search term: rpoC Search term: DNA-directed RNA polymerase subunit beta'

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000502190 RNA polymerase II subunit A [Source:HGNC Symbol;Acc:HGNC:9187] E-value: 3.0e-46 Percent Identity: 24.9
Ensembl 110, assembly GRCh38.p14	ENSP00000494840 RNA polymerase II subunit A [Source:HGNC Symbol;Acc:HGNC:9187] E-value: 3.0e-46 Percent Identity: 24.9

References