Pseudomonas aeruginosa UCBPP-PA14, PA14_09220 (pchB)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_09220
Name	pchB
Replicon	chromosome
Genomic location	781694 - 781999 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	3 transposon mutants in orthologs

Cross-References

RefSeq	YP_788889.1
GI	116052267
Entrez	4382938
INSDC	ABJ13503.1
NCBI Locus Tag	PA14_09220
UniParc	UPI00003962FE
UniProtKB Acc	Q02T47
UniProtKB ID	Q02T47_PSEAB
UniRef100	UniRef100_Q02T47
UniRef50	UniRef50_Q51507
UniRef90	UniRef90_Q51507

Product

Feature Type	CDS
Coding Frame	1
Product Name	isochorismate-pyruvate lyase
Synonyms
Evidence for Translation
Charge (pH 7)	-2.80
Kyte-Doolittle Hydrophobicity Value	-0.299
Molecular Weight (kDa)	11.4
Isoelectric Point (pI)	4.87

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3RET	LYASE	04/05/11	Salicylate and Pyruvate Bound Structure of the Isochorismate-Pyruvate Lyase K42E Mutant from Pseudomonas aerugionsa	Pseudomonas aeruginosa	1.79	X-RAY DIFFRACTION	97.0
3HGX	LYASE	05/14/09	Crystal Structure of Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase K42A mutant in complex with salicylate and pyruvate	Pseudomonas aeruginosa	2.5	X-RAY DIFFRACTION	97.0
2H9D	LYASE	06/09/06	Pyruvate-Bound Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aerugionsa	Pseudomonas aeruginosa	1.95	X-RAY DIFFRACTION	98.0
3HGW	LYASE	05/14/09	Apo Structure of Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase I87T mutant	Pseudomonas aeruginosa	2.25	X-RAY DIFFRACTION	97.0
3REM	LYASE	04/04/11	Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aerugionsa with Bound Salicylate and Pyruvate	Pseudomonas aeruginosa	1.95	X-RAY DIFFRACTION	98.0
2H9C	LYASE	06/09/06	Native Crystal Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.35	X-RAY DIFFRACTION	98.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 65 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000704 (672 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_09220 Search term: pchB Search term: isochorismate-pyruvate lyase

Human Homologs

References